Extract of Jasminum grandiflorum L. alleviates CCl4-induced liver injury by decreasing inflammation, oxidative stress and hepatic CYP2E1 expression in mice

文献类型： 外文期刊

第一作者： Sun, Lingli

作者： Sun, Lingli;Wen, Shuai;Li, Qiuhua;Chen, Ruohong;Lai, Xingfei;Zhang, Zhenbiao;Sun, Shili;Zhang, Yizi;Zhou, Zhiyan;Xie, Yinzheng;Zheng, Xi;Zhang, Kun;Li, Dongli;Zheng, Xi;Zhang, Kun;Li, Dongli

作者机构：

关键词： Liver injury; Inflammation Oxidative stress; Jasminum grandiflorum L.

期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：7.419； 五年影响因子：6.581 ）

ISSN： 0753-3322

年卷期： 2022 年 152 卷

页码：

收录情况： SCI

摘要： Jasminum grandiflorum L. (JG) is a medicinal plant containing many bioactive ingredients. Herein, we analyzed the effects of four different extracts and two compounds of JG on acute liver injury caused by carbon tetrachloride (CCl4) and underlying molecular mechanisms. 7 weeks old C57BL/6 male mice were used to establish a liver injury model by injecting with 1% CCl4, 10 mL/kg ip. Four different extracts and two compounds of JG were given to mice by gavage for 3 days. Clinical and histological chemistry assays were performed to assess liver injury. Moreover, hepatic oxidative stress and inflammation related markers were determined by immunohistochemistry and western blotting. As a result, JG extracts and two functional components showed different degree of protect effects against CCl4-induced liver injury by the decrease of elevated serum transaminases and liver index, and the attenuation of histopathological changes in mice, among which JG extracted with petroleum ether (PET) had the most significant effect. In addition, PET remarkably alleviated hepatic oxidative stress and inflammation. Further studies revealed that PET significantly inhibited the TNF- alpha expression, signal pathway expression, NF-kappa B p65 and inflammatory factors IL-1 ss and IL-6 expression in CCl4-induced liver injury mice. Nevertheless, hydroxytyrosol (HT) alleviated liver injury by reducing oxidative stress. Apart from PET extract, other extracts of JG can inhibit cytochrome CYP2E1 expression to protect liver tissue. These findings suggest that the extracts and its components of JG possesses the potential protective effects against CCl4-induced liver injury in mice by exerting antioxidative stress and anti-inflammation.

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