Effects of whole grain intake on glycemic traits: A systematic review and meta-analysis of randomized controlled trials

文献类型： 外文期刊

第一作者： Li, Shixiang

作者： Li, Shixiang;Zong, Aizhen;An, Ran;Wang, Haiou;Liu, Lina;Du, Fangling;Xu, Tongcheng;Li, Shixiang;Zong, Aizhen;Xu, Zhixiang;Xu, Tongcheng;An, Ran;Xu, Tongcheng;Liu, Jie;Wang, Jing;Xu, Tongcheng;Guo, Xiaofei;Li, Duo

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关键词： Glucose; HbA1c; HOMA-IR; insulin; whole grains

期刊名称：CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION （ 影响因子：11.176； 五年影响因子：11.193 ）

ISSN： 1040-8398

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收录情况： SCI

摘要： Whole grains (WGs) may have various health benefits, including lowering blood glucose and improving insulin sensitivity. To conduct a meta-analysis of the effects of WGs compared with non-WGs on changes in fasting glucose, fasting insulin, glycated hemoglobin (HbA1c), and homeostasis model assessment of insulin resistance (HOMA-IR). A systematic literature search was performed for all published randomized controlled trials on the effects of WG intake on fasting glucose, fasting insulin, HbA1c and HOMA-IR response up to February 2021. Weighted mean differences (WMD) were calculated. Pre-specified subgroup and univariate meta-regression analyses were explored to identify the sources of heterogeneity. Sensitivity analysis and bias analysis were conducted to appraise study quality. Among 12,435 articles screened for eligibility, data were extracted from 48 articles. Meta-analysis of 4,118 participants showed that WG consumption resulted in a significant reduction in fasting glucose by -0.15 mmol/L, fasting insulin by -2.71 pmol/L, HbA1c by -0.44%, and HOMA-IR by -0.28, respectively. Compared with mixed grains, brown rice, and wheat, oats were significantly lower on marker of glycemic. Besides, multiple interventions per day consolidated effectiveness of WGs. WG consumption decreased the levels of fasting glucose, fasting insulin, HbA1c, and HOMA-IR compared with non-WG consumption.

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