Piezoelectric dual network dressing with adaptive electrical stimulation for diabetic infected wound repair via antibacterial, antioxidant, anti-inflammation, and angiogenesis
文献类型： 外文期刊
第一作者： Ren, Jian
作者： Ren, Jian;Wang, Xinru;Bao, Tianjing;Shen, Xiaoyu;Yin, Dongyue;Deng, Chunlin;Ren, Jian;Wang, Xinru;Bao, Tianjing;Xiao, Cairong;Deng, Chunlin;Shen, Xiaoyu;Yin, Dongyue;Deng, Chunlin;Liang, Qingyou;Sun, Shili
作者机构：
关键词： Metal-polyphenol network; Adaptive electrical stimulation; Diabetic wound; Antibacterial; Anti-inflammatory
期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：13.3； 五年影响因子：13.2 ）
ISSN： 1385-8947
年卷期： 2024 年 491 卷
页码：
收录情况： SCI
摘要： Electrical stimulation therapy plays a crucial role in the healing of wounds. However, electrical stimulation based on piezoelectric materials faces limitations in dynamically matching cell activity and lacks anti-infection properties, thereby restricting its broader clinical application. Herein, a piezoelectric dual network nanofiber dressing (CuEG/PVDF) was prepared using copper/ epigallocatechin 3-gallate (Cu2+/EGCG) and polyvinylidene fluoride (PVDF). This dressing constructs dynamic force-electrical closed-loop feedback signals through cell adhesion and adaptive electrical stimulation to accelerate the healing of infectious diabetic wounds. Benefiting for the Cu2+EGCG metal-polyphenol network, it enhances the electromechanical coupling properties, hydrophilicity, and cell adhesion of the piezoelectric double network dressing. Cell proliferation and migration were promoted by increased adhesion area, enhanced adaptive electrical stimulation, and active calcium influx. Moreover, CuEG/ PVDF demonstrate significant antibacterial, antioxidant, anti-inflammatory, and angiogenic activities. In vivo experiments demonstrate that this dual-network piezoelectric dressing reduces the inflammatory response in rats, eliminates Methicillin-resistant Staphylococcus aureus (MRSA), and accelerates wound repair. Overall, this study presents a promising strategy for implementing electrical stimulation in the treatment of infected wounds.
分类号：
- 相关文献
作者其他论文 更多>>
-
Mechanism of Green Tea Peptides in Lowering Blood Pressure and Alleviating Renal Injury Induced by Hypertension Through the Ang II/TGF-β1/SMAD Signaling Pathway
作者：Li, Lulu;Li, Dongli;Li, Lulu;Sun, Shili;Lai, Xingfei;Li, Qiuhua;Chen, Ruohong;Zhang, Zhenbiao;Hao, Mengjiao;Zhang, Suwan;Sun, Lingli;Li, Dongli
关键词：tea polypeptide; hypertension; renal injury; TGF-beta/Smad signaling
-
Metabolomics-based analysis of the effects of differences in soluble sugars on the sweetness quality of six major tea types in China
作者：Li, Wen;Chen, Zhongzheng;Zhang, Zhenbiao;Chen, Ruohong;Sun, Lingli;Lai, Xingfei;Li, Qiuhua;Hao, Mengjiao;Zhang, Suwang;Sun, Shili;Li, Qian
关键词：
-
Effects of Pile-Fermentation Duration on the Taste Quality of Single-Cultivar Large-Leaf Dark Tea: Insights from Metabolomics and Microbiomics
作者：Yang, Wanying;Ni, He;Chen, Ruohong;Sun, Lingli;Li, Qiuhua;Lai, Xingfei;Zhang, Zhenbiao;Lai, Zhaoxiang;Hao, Mengjiao;Sun, Shili;Li, Qian;Lin, Sen
关键词：dark tea; quality; taste; pile-fermentation; metabolomics; microbiomics
-
Analysis of volatile metabolites and differences in aroma quality of green tea, black tea and oolong tea prepared from highly aromatic tea variety (Dancong)
作者：Zhang, Suwan;Xia, Hongling;Sun, Shili;Ma, Chenying;Pan, Shunshun;Zhang, Zhenbiao;Lai, Xingfei;Li, Qiuhua;Hao, Mengjiao;Sun, Lingli;Chen, Ruohong;Zhang, Suwan;Xia, Hongling;Sun, Shili;Ma, Chenying;Pan, Shunshun;Zhang, Zhenbiao;Lai, Xingfei;Li, Qiuhua;Hao, Mengjiao;Sun, Lingli;Chen, Ruohong;Li, Feng;Ma, Chenying
关键词：Fermentation degree; Tea; Aroma; VOCs; GC-MS
-
One versus many independent assemblies of symbiotic nitrogen fixation in flowering plants
作者：Doyle, Jeff J.;Doyle, Jeff J.;Ren, Jian;Gao, Yingzhi;Ren, Jian;Pawlowski, Katharina;James, Euan K.;Gao, Yingzhi
关键词：
-
A 3D point cloud and deep learning based automated process for quantifying multi-scale phenotypes in sliced bread
作者：Zhou, Honghao;Qin, Bingxi;Chen, Jiawei;Zhou, Honghao;Zhou, Qin;Wang, Xinru;Min, Haijiang;Qin, Bingxi;Liang, Shaowei;Wang, Xiao;Zhong, Yingxin;Cai, Jian;Huang, Mei;Li, Qing;Jiang, Dong;Chen, Jiawei;Zhang, Jungao;Zhang, Jungao;Zhang, Jungao
关键词：Sliced bread; Line scanning laser; 3D deep learning model; Pore 3D trait analysis
-
Inhibition of xanthine oxidase by copper-gallate coordination polymers and its mechanistic study
作者：Mo, Yejian;Ren, Jian;Sun, Shili;Shen, Xiaoyu;Mo, Yejian;Ren, Jian;Liu, Kexin;Deng, Chunlin;Shen, Xiaoyu;Mo, Yejian;Ren, Jian;Liu, Kexin;Deng, Chunlin
关键词：Hyperuricemia; Metal-polyphenol coordination polymers; Xanthine oxidase inhibitors; Antioxidant properties
