Piezoelectric dual network dressing with adaptive electrical stimulation for diabetic infected wound repair via antibacterial, antioxidant, anti-inflammation, and angiogenesis

文献类型： 外文期刊

第一作者： Ren, Jian

作者： Ren, Jian;Wang, Xinru;Bao, Tianjing;Shen, Xiaoyu;Yin, Dongyue;Deng, Chunlin;Ren, Jian;Wang, Xinru;Bao, Tianjing;Xiao, Cairong;Deng, Chunlin;Shen, Xiaoyu;Yin, Dongyue;Deng, Chunlin;Liang, Qingyou;Sun, Shili

作者机构：

关键词： Metal-polyphenol network; Adaptive electrical stimulation; Diabetic wound; Antibacterial; Anti-inflammatory

期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：13.3； 五年影响因子：13.2 ）

ISSN： 1385-8947

年卷期： 2024 年 491 卷

页码：

收录情况： SCI

摘要： Electrical stimulation therapy plays a crucial role in the healing of wounds. However, electrical stimulation based on piezoelectric materials faces limitations in dynamically matching cell activity and lacks anti-infection properties, thereby restricting its broader clinical application. Herein, a piezoelectric dual network nanofiber dressing (CuEG/PVDF) was prepared using copper/ epigallocatechin 3-gallate (Cu2+/EGCG) and polyvinylidene fluoride (PVDF). This dressing constructs dynamic force-electrical closed-loop feedback signals through cell adhesion and adaptive electrical stimulation to accelerate the healing of infectious diabetic wounds. Benefiting for the Cu2+EGCG metal-polyphenol network, it enhances the electromechanical coupling properties, hydrophilicity, and cell adhesion of the piezoelectric double network dressing. Cell proliferation and migration were promoted by increased adhesion area, enhanced adaptive electrical stimulation, and active calcium influx. Moreover, CuEG/ PVDF demonstrate significant antibacterial, antioxidant, anti-inflammatory, and angiogenic activities. In vivo experiments demonstrate that this dual-network piezoelectric dressing reduces the inflammatory response in rats, eliminates Methicillin-resistant Staphylococcus aureus (MRSA), and accelerates wound repair. Overall, this study presents a promising strategy for implementing electrical stimulation in the treatment of infected wounds.

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