The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony

文献类型： 外文期刊

第一作者： Wang, Jin-Lei

作者： Wang, Jin-Lei;Li, Ting-Ting;Zhang, Nian-Zhang;Wang, Meng;Sun, Li-Xiu;Zhang, Zhi-Wei;Fu, Bao-Quan;Elsheikha, Hany M.;Zhu, Xing-Quan

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期刊名称：NATURE COMMUNICATIONS （ 影响因子：16.6； 五年影响因子：17.0 ）

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年卷期： 2024 年 15 卷 1 期

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收录情况： SCI

摘要： Sexual development in Toxoplasma gondii is a multistep process that culminates in the production of oocysts, constituting approximately 50% of human infections. However, the molecular mechanisms governing sexual commitment in this parasite remain poorly understood. Here, we demonstrate that the transcription factors AP2XI-2 and AP2XII-1 act as negative regulators, suppressing merozoite-primed pre-sexual commitment during asexual development. Depletion of AP2XI-2 in type II Pru strain induces merogony and production of mature merozoites in an alkaline medium but not in a neutral medium. In contrast, AP2XII-1-depleted Pru strain undergoes several rounds of merogony and produces merozoites in a neutral medium, with more pronounced effects observed under alkaline conditions. Additionally, we identified two additional AP2XI-2-interacting proteins involved in repressing merozoite programming. These findings underscore the intricate regulation of pre-sexual commitment by a network of factors and suggest that AP2XI-2 or AP2XII-1-depleted Pru parasites can serve as a model for studying merogony in vitro.

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