Aronia Melanocarpa Elliot Anthocyanins Inhibits Alcoholic Liver Disease by Activation of α7nAChR

文献类型： 外文期刊

第一作者： Wei, Jie

作者： Wei, Jie;Tang, Xian;He, Yujing;Peng, Ziheng;Liu, Hongwei;He, Yin;Gao, Jun

作者机构：

关键词： Rowan anthocyanins; Alcoholic liver damage; PI3K-Akt signaling pathway

期刊名称：PLANT FOODS FOR HUMAN NUTRITION （ 影响因子：3.1； 五年影响因子：3.8 ）

ISSN： 0921-9668

年卷期： 2024 年

页码：

收录情况： SCI

摘要： The study wanted to explore the preventative effects of Aornia melanocarpa Elliot anthocyanins (AMA) to Alcoholic liver disease (ALD) by bioinformatics prediction and experimental verification. We founded 419 differentially expressed genes (DEGs) in GSE28619 related to ALD from GEO database, COL1A1 was selected by the core gene module construction and molecular docking. Mice were treated by intragastric administration of gradient 50% ethanol, AMA alleviated liver injury by ALD and ameliorated the model's body weight, lessened the liver inflammation according to histopathological evaluation, increased serum liver biochemical index (AST, ALT, TC, TG and LDL-C) and decreased HDL-C, reversed the expression of enzymes (ALDH and GSH-PX), decreased cytokines expression (Ki67, TNF-alpha and IL-6), reversed the expression of alpha 7nAChR and collagen I, downregulated the PI3K-Akt pathway and Keap1/HO-1 pathway (p-PI3K, PI3K, p-Akt, Akt, Keap1, Nrf2, HO-1,GSK-3 beta and Bcl-2), indicated that alpha 7nAChR and collagen I may be the AMA action targets.Graphical AbstractAorniamelanocarpa Elliot anthocyanins (AMA) could alleviate alcoholic liver disease (ALD) induced by ethanol by regulating PI3K-Akt and Keap1/HO-1 pathways.

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