Selection at the GSDMC locus in horses and its implications for human mobility

文献类型： 外文期刊

第一作者： Liu, Xuexue

作者： Liu, Xuexue;Pan, Jianfei;Orlando, Ludovic;Liu, Xuexue;Jia, Yaozhen;Pan, Jianfei;Zhang, Yanli;Gong, Ying;Wang, Xintong;Ma, Yuehui;Jiang, Lin;Liu, Xuexue;Alvarez, Nadir;Alvarez, Nadir;Alvarez, Nadir

作者机构：

期刊名称：SCIENCE （ 影响因子：45.8； 五年影响因子：49.7 ）

ISSN： 0036-8075

年卷期： 2025 年 389 卷 6763 期

页码：

收录情况： SCI

摘要： Horsepower revolutionized human history through enhanced mobility, transport, and warfare. However, the suite of biological traits that reshaped horses during domestication remains unclear. We scanned an extensive horse genome time series for selection signatures at 266 markers associated with key traits. We detected a signature of positive selection at ZFPM1-known to be a modulator of behavior in mice-occurring similar to 5000 years ago (ya), suggesting that taming was one of the earliest steps toward domestication of horses. Intensive selection at GSDMC began similar to 4750 ya with the domestication bottleneck, leading regulatory variants to high frequency by similar to 4150 ya. GSDMC genotypes are linked to body conformation in horses and to spinal anatomy, motor coordination, and muscular strength in mice. Our results suggest that selection on standing variation at GSDMC was crucial for the emergence of horses that could facilitate fast mobility in human societies similar to 4200 ya.

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