Impact of quorum sensing signaling molecules in gram-negative bacteria on host cells: current understanding and future perspectives

文献类型： 外文期刊

第一作者： Xiao, Yingping

作者： Xiao, Yingping;Lv, Wentao;Wang, Wen;Xiao, Yingping;Lv, Wentao;Wang, Wen;Zou, Huicong;Li, Jingjing;Song, Tongxing;Tao, Shiyu;Wang, Zhenyu

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关键词： Quorum sensing; gram-negative bacteria; signaling molecule; host cell; gut health

期刊名称：GUT MICROBES （ 影响因子：9.434； 五年影响因子：11.724 ）

ISSN： 1949-0976

年卷期： 2022 年 14 卷 1 期

页码：

收录情况： SCI

摘要： Quorum sensing is a molecular signaling-based communication mechanism in prokaryotes. In the basic mode, signaling molecules released by certain bacteria are sensed by intracellular receptors or membrane-bound receptors of other members in the community, leading to the collective isogenic signaling molecule synthesis and synchronized activities. This regulation is important for the symbiosis of the bacterium with the host, as well as virulence and biofilm formation. Notably, quorum sensing signaling molecules are not only able to control microbial community behavior but can likewise regulate the physiological status of host cells. Here, we provide a comprehensive review of the importance of quorum sensing signaling molecules in gram-negative bacteria in regulating host cell function and gut health, and suggest possible opportunities for application in combating human and animal diseases by blocking the pathways through which quorum sensing signaling molecules exert their functions.

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