Deciphering Trachinotus ovatus resistance to Streptococcus agalactiae:GWAS :GWAS identification of key SNPs and candidate genes

文献类型： 外文期刊

第一作者： Sun, Yi-Yao

作者： Sun, Yi-Yao;Gao, Jie;Liu, Bao-Suo;Zhang, Nan;Guo, Hua-Yang;Zhu, Ke-Cheng;Xian, Lin;Zhang, Dian-Chang;Sun, Yi-Yao;Liu, Bao-Suo;Zhang, Nan;Guo, Hua-Yang;Zhu, Ke-Cheng;Xian, Lin;Zhang, Dian-Chang;Liu, Bao-Suo;Zhang, Nan;Zhu, Ke-Cheng;Zhang, Dian-Chang;Gao, Jie

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关键词： GWAS; Trachinotus ovatus; Streptococcus agalactiae; SNP

期刊名称：AQUACULTURE （ 影响因子：3.9； 五年影响因子：4.1 ）

ISSN： 0044-8486

年卷期： 2025 年 594 卷

页码：

收录情况： SCI

摘要： The genetic basis of resistance in Trachinotus ovatus to Streptococcus agalactiae, , a prevalent pathogen in warm- water fish, was explored in this study. T. ovatus, , an economically significant marine fish, is widely distributed in tropical and subtropical oceans. This research involved the whole-genome resequencing of 200 T. ovatus individuals and a genome-wide association study (GWAS) to identify significant single nucleotide polymorphisms (SNPs) associated with resistance to S. agalactiae. . Methods included infection experiments with S. agalactiae, , quality control of DNA samples, high-throughput sequencing, SNP detection and quality control, analysis of population genetic structure, linkage disequilibrium (LD) analysis, GWAS, screening of candidate genes, and genotyping of significant SNPs. Results indicated a significant association of specific SNP loci with resistance in T. ovatus to S. agalactiae, , notably SNP18597184 on chromosome LG9, associated with the NTRK3 and IFNK genes involved in neural development, survival, and immune response.

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