Lignocellulosic biomass as promising substrate for polyhydroxyalkanoate production: Advances and perspectives

文献类型： 外文期刊

第一作者： Li, Dongna

作者： Li, Dongna;Wang, Fei;Zheng, Xuening;Zheng, Yingying;Pan, Xiaosen;Ma, Xiaojun;Yin, Fen;Li, Dongna;Wang, Qiang;Li, Jianing

作者机构：

关键词： Lignocellulosic biomass; Polyhydroxyalkanoate; Greener pretreatments; Metabolic pathway; Techno-economic analysis; Life cycle assessment; Circular bioeconomy

期刊名称：BIOTECHNOLOGY ADVANCES （ 影响因子：12.5； 五年影响因子：15.7 ）

ISSN： 0734-9750

年卷期： 2025 年 79 卷

页码：

收录情况： SCI

摘要： The depletion of fossil resources, coupled with global warming and adverse environmental impact of traditional petroleum-based plastics, have necessitated the discovery of renewable resources and innovative biodegradable materials. Lignocellulosic biomass (LB) emerges as a highly promising, sustainable and eco-friendly approach for accumulating polyhydroxyalkanoate (PHA), as it completely bypasses the problem of "competition for food". This sustainable and economically efficient feedstock has the potential to lower PHA production costs and facilitate its competitive commercialization, and support the principles of circular bioeconomy. LB predominantly comprises cellulose, hemicellulose, and lignin, which can be converted into high-quality substrates for PHA production by various means. Future efforts should focus on maximizing the value derived from LB. This review highlights the momentous and valuable research breakthroughs in recent years, showcasing the biosynthesis of PHA using low-cost LB as a potential feedstock. The metabolic mechanism and pathways of PHA synthesis by microbes, as well as the key enzymes involved, are summarized, offering insights into improving microbial production capacity and fermentation metabolic engineering. Life cycle assessment and technoeconomic analysis for sustainable and economical PHA production are introduced. Technological hurdles such as LB pretreatment, and performance limitations are highlighted for their impact on enhancing the sustainable production and application of PHA. Meanwhile, the development direction of co-substrate fermentation of LB and with other carbon sources, integrated processes development, and co-production strategies were also proposed to reduce the cost of PHA and effectively valorize wastes.

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