Cashmere cyclic growth affected by different photoperiods alters DNA methylation patterns

文献类型： 外文期刊

第一作者： Zhao, Ruoyang

作者： Zhao, Ruoyang;Wu, Tiecheng;Wang, Tao;Gao, Yulin;Liu, Bin;Zhao, Ruoyang;Yin, Jun;Wang, Tao;He, Yunmei;Wu, Yahan

作者机构：

关键词： Goat cashmere; hair follicle; DNA methylation; sequencing; DMRs; light duration

期刊名称：ALL LIFE （ 影响因子：1.1； 五年影响因子：1.1 ）

ISSN： 2689-5293

年卷期： 2024 年 17 卷 1 期

页码：

收录情况： SCI

摘要： Whole-genome bisulfite sequencing was used to study epigenetic differences in hair follicles from Inner Mongolia Albas cashmere goats during long and short photoperiods. Results showed earlier anagen entry in short photoperiod. Genome-wide cytosine methylation was 3.23%, with CG, CHG, and CHH methylation rates at 48.00%, 0.19%, and 0.17%, respectively. Methylation was higher for CG than for CHG and CHH, and higher for introns than exons and downstream regions. Both groups had similar levels of CG, CHG, and CHH methylation, but CHH methylation levels differed slightly between photoperiods. A total of 9,700 differentially methylated regions (DMRs) and 4,187 genes (DMGs) were identified. Gene Ontology (GO) and KEGG analyses revealed significant enrichment in 67 GO terms and 41 signaling pathways related to circadian rhythms, bringing new insights in the role of DNA methylation in cashmere growth and development.

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