EspE3 plays a role in the pathogenicity of avian pathogenic Escherichia coli

文献类型： 外文期刊

第一作者： Li, Qianwen

作者： Li, Qianwen;Qi, Zhao;Fu, Dandan;Song, Xiangjun;Shao, Ying;Tu, Jian;Qi, Kezong;Li, Qianwen;Qi, Zhao;Fu, Dandan;Song, Xiangjun;Shao, Ying;Tu, Jian;Qi, Kezong;Li, Qianwen;Tang, Bo;Li, Qianwen;Tang, Bo;Li, Qianwen;Tang, Bo

作者机构：

关键词： APEC; ETT2; effector; EspE3; pathogenicity

期刊名称：VETERINARY RESEARCH （ 影响因子：4.4； 五年影响因子：4.3 ）

ISSN： 0928-4249

年卷期： 2023 年 54 卷 1 期

页码：

收录情况： SCI

摘要： APEC encodes multiple virulence factors that have complex pathogenic mechanisms. In this study, we report a virulence factor named EspE3, which can be secreted from APEC. This protein was predicted to have a leucine-rich repeat domain (LRR) and may have a similar function to IpaH class effectors of the type III secretion system (T3SS). For further exploration, the regulatory correlation between the espE3 and ETT2 genes in APEC was analysed. We then assessed the pathogenicity of EspE3, detected it in APEC secretion proteins and screened the proteins of EspE3 that interact with chicken trachea epithelial cells. This study provides data on a new virulence factor for further exploring the pathogenic mechanism of APEC.

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