Oxygen Vacancy-Rich Amorphous MOF/Graphene Nanozymes With Self-Sustaining Catalytic Circuits for Drug-Resistant Infection Wound Healing

文献类型： 外文期刊

第一作者： Zhao, Xiaoping

作者： Zhao, Xiaoping;Deng, Yuanjie;Meng, Lingjie;Zhao, Xiaoping;Sun, Heng;Liu, Zhicheng;Jing, Xunan;Meng, Lingjie;Wang, Tingan;Wang, Tingan

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关键词： amorphous metal organic frameworks; cascade reaction; chemo-dynamic therapy; nanozyme; peroxidase-like

期刊名称：ADVANCED HEALTHCARE MATERIALS （ 影响因子：9.6； 五年影响因子：10.8 ）

ISSN： 2192-2640

年卷期： 2025 年

页码：

收录情况： SCI

摘要： Diabetic chronic wounds, driven by hyperglycemia-induced oxidative stress and multidrug-resistant bacterial infections, represent a highly challenging clinical issue. Existing therapies fall short in addressing the dual challenges of bacterial resistance and dysregulated wound microenvironments. Although metal-organic framework (MOF)-based nanozymes hold potential for catalytic antibacterial therapy, their clinical application is limited by insufficient active site exposure, structural instability of amorphous MOFs (aMOFs), and dependence on toxic exogenous H2O2. Here, a triple-engineered cascade nanozyme (aMrGG) is presented that synergizes amorphous Fe-MOF chemistry, graphene interface engineering, and glucose-fueled metabolic reprogramming to overcome these barriers. Through thermal reduction-induced amorphization, aMOFs exhibit a 2.1-fold enhancement in peroxidase-like activity, driven by abundant oxygen vacancies and an optimized Fe-2(+)/Fe-3(+) ratio. Mechanochemical anchoring of aMOFs onto reduced graphene oxide (rGO) stabilizes catalytic performance and enhances charge transfer, resulting in a 13.3-fold increase in hydroxyl radical (OH) generation. The self-sustaining cascade system, powered by endogenous glucose in diabetic wounds, produces nontoxic H2O2 and lowers the pH to 3.5, activating nanozyme activity while protonating bacterial membranes for targeted OH attack. In vivo, aMrGG achieves >99.999% eradication of MRSA and E. coli, accelerates wound healing. This study pioneers the amorphous materials in microenvironment-adaptive nanomedicinefor diabetic wound management.

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