In-depth profiling of Phenolics in strawberries and their potential modulatory effects on the oxidative stress-disease Axis: Insights from UHPLC-QTOF-MS-based untargeted metabolomics, network pharmacology, and molecular docking

文献类型： 外文期刊

第一作者： Zeng, Zhiyuan

作者： Zeng, Zhiyuan;Xu, Jiayue;Tian, Xiaoyu;Zhao, Liang;Liao, Xiaojun;Zeng, Zhiyuan;Xu, Jiayue;Tian, Xiaoyu;Zhao, Liang;Liao, Xiaojun;Xu, Lei

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关键词： Phenolics; Oxidative stress-disease axis; UHPLC-QTOF-MS; Untargeted metabolomics; Network pharmacology; Molecular docking; Strawberries (Fragaria x ananassa cv. 'Benihoppe')

期刊名称：FOOD CHEMISTRY （ 影响因子：9.8； 五年影响因子：9.7 ）

ISSN： 0308-8146

年卷期： 2025 年 489 卷

页码：

收录情况： SCI

摘要： Strawberry phenolics, contributing to its potent antioxidant properties, yet due to limitations in detection and analysis techniques, the phenolic profiling of strawberries remains incomplete, hindering a deeper understanding of their mechanisms. In this study, a dual-phase extraction method was applied to extract both free and bound phenolics, followed by UHPLC-QTOF-MS-based untargeted metabolomics. A total of 57 phenolics were annotated, with 12 further identified using standards. Notably, twenty-six phenolics were first reported in strawberries. Network pharmacology analysis revealed that phenolic targets associated with oxidative stress-driven disease are primarily enriched in SRC, PIK3CA, PIK3R1, HSP90AA1, and TP53, which exert their effects through the PI3K-AKT signaling pathway. Molecular docking simulations further elucidated the interaction mechanisms, suggesting that strawberry phenolics modulate the oxidative stress-disease axis. These findings have enhanced our understanding of the phenolic profile of strawberries and lay the groundwork for further research into the physiological roles of strawberry phenolics.

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