Transparent injectable sericin-honey hydrogel with antioxidant and antibacterial activities combined with feeding sericin accelerates diabetic wound healing

文献类型： 外文期刊

第一作者： Wei, Yongkang

作者： Wei, Yongkang;Li, Yanwei;Li, Yurong;Li, Xiang;Ye, Ruixi;Xi, Meilin;Zhang, Guozheng;Zhang, Yeshun;Li, Yurong;Zhang, Guozheng;Zhang, Yeshun;Xu, Gang;Li, Xiaomei;Wu, Tangfeng;Zhang, Yeshun

作者机构：

关键词： sericin; honey; biocompatibility; diabetic wound healing

期刊名称：BIOMEDICAL MATERIALS （ 影响因子：4.0； 五年影响因子：4.0 ）

ISSN： 1748-6041

年卷期： 2024 年 19 卷 3 期

页码：

收录情况： SCI

摘要： Wound healing in diabetics is often impaired or delayed due to the presence of high reactive oxygen species and low antioxidant levels. Here, a sericin-honey semi-interpenetrating network hydrogel with excellent antioxidant activity was prepared. Besides, the sericin-honey hydrogel is transparent, injectable, sticky, highly porous, and has good swelling properties, antibacterial activity, and cell compatibility. Based on its good performance in vitro, sericin-honey hydrogel achieved effective in vivo treatment on a mouse diabetic wound model, significantly accelerating the wound healing process. Furthermore, the combined effect of feeding sericin solution played a positive role in strengthening the effect of diabetic wound repair.

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