Content analysis and drug safety evaluation of four furanocoumarins in six pomelos produced in China

文献类型： 外文期刊

第一作者： Chen, Weiling

作者： Chen, Weiling;Li, Zeqi;Li, Jiaqi;Gu, Qiuming;Cheng, Yujiao;Li, Guijie;Huang, Linhua;Wu, Houjiu;Cheng, Yujiao;Li, Guijie;Huang, Linhua;Wu, Houjiu

作者机构：

关键词： Pomelo juice; furanocoumarin; cytochrome enzyme; medication safety

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.2； 五年影响因子：2.3 ）

ISSN： 1478-6419

年卷期： 2023 年

页码：

收录情况： SCI

摘要： The content of 4 6',7'-dihydroxybergamottin (DHB), bergamottin, isoimperatorin and epoxybergamottin of six pomelos produced in China were detected by High-performance liquid chromatography-diode array detection and their safety of related medicines was evaluated by inhibition of medium concentration (IC50) of cytochrome oxidases CYP450-like. The results showed that the total content of the four furanocoumarins in these pomelo juices from high to low in order was Guanximi pomelo > Liangping pomelo > Pinghemi pomelo > grapefruit > Huyou > Shatian pomelo. The concentration of isoimperatorin in grapefruit, DHB, bergamottinand and isoimperatorin in Liangping, bergamottin and epoxybergamottin in Pinghemi and all the four furanocoumarins in Guanximi were exceeded the corresponding IC50; although Huyou and Shatian contained some furanocoumarins, they did not exceed IC50. Therefore, when taking drugs metabolised by CYP450-like enzymes, Guanximi, Liangping, Pinghemi, and grapefruit should be avoided to consume, but it is relatively safe to eat Huyou and Shatian.

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