Lentogenic NDV V protein inhibits IFN responses and represses cell apoptosis

文献类型： 外文期刊

第一作者： Nan, Fu Long

作者： Nan, Fu Long;Xu, Xiao Hong;Zhang, Ying;Jin, Ning Yi;Nan, Fu Long;Zhang, He;Xie, Chang Zhan;Ha, Zhuo;Lu, Hui Jun;Jin, Ning Yi;Nan, Wen Long;Chen, Xing;Qian, Jing;Qiu, Xu Sheng;Ge, Jin Ying;Bu, Zhi Gao

作者机构：

关键词： NDV; V Protein; Virulence; IFN antagonist; Apoptosis

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN： 0378-1135

年卷期： 2021 年 261 卷

页码：

收录情况： SCI

摘要： The V protein of Newcastle disease virus (NDV) has been shown to inhibit the secretion of interferon (IFN) during infection, which is responsible for the promotion of NDV pathogenicity. However, the ability of the V protein to suppress host innate immunity is not well understood. In this study, we explored the function of V protein and its relationship with virulence by generating V protein-inserted recombinant (r) NDVs. Using rNDVs as a model, we examined the efficiency of infection, IFN responses, and apoptosis of host cells during infection. We found that viral propagation occurred smoothly when V protein from lentogenic NDV is inserted instead of the V protein from the velogenic strain. The infection of lentogenic V protein-inserted rNDV induced less expression of IFNs and downstream antiviral proteins via efficient degradation of p-STAT1 and MDA5. Moreover, velogenic V protein triggered a higher apoptosis rate during infection thereby restricting the replication of NDV. Conversely, lentogenic V protein inhibits IFN responses efficiently and induces less apoptosis compared to the velogenic strain. Our findings provide a novel understanding of the role of V protein in NDV pathogenicity.

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