文献类型： 外文期刊
第一作者： Yang, Xue
作者： Yang, Xue;Jia, Zi-Chang;Chen, Mo-Xian;Hao, Ge-Fei;Li, Min;Liu, Yan;Wu, Shun-Fan;Yang, Qing
作者机构：
关键词： Drug resistance; Membrane proteins; Convergent evolution; Mechanisms
期刊名称：DRUG RESISTANCE UPDATES （ 影响因子：21.7； 五年影响因子：23.0 ）
ISSN： 1368-7646
年卷期： 2024 年 77 卷
页码：
收录情况： SCI
摘要： Membrane protein-mediated resistance is a multidisciplinary challenge that spans fields such as medicine, agriculture, and environmental science. Understanding its complexity and devising innovative strategies are crucial for treating diseases like cancer and managing resistant pests in agriculture. This paper explores the dual nature of resistance mechanisms across different organisms: On one hand, animals, bacteria, fungi, plants, and insects exhibit convergent evolution, leading to the development of similar resistance mechanisms. On the other hand, influenced by diverse environmental pressures and structural differences among organisms, they also demonstrate divergent resistance characteristics. Membrane protein-mediated resistance mechanisms are prevalent across animals, bacteria, fungi, plants, and insects, reflecting their shared survival strategies evolved through convergent evolution to address similar survival challenges. However, variations in ecological environments and biological characteristics result in differing responses to resistance. Therefore, examining these differences not only enhances our understanding of adaptive resistance mechanisms but also provides crucial theoretical support and insights for addressing drug resistance and advancing pharmaceutical development.
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