Phylogenetic and Genetic Variation Analysis of Porcine Epidemic Diarrhea Virus in East Central China during 2020-2023

文献类型： 外文期刊

第一作者： Sun, Liumei

作者： Sun, Liumei;Li, Duo;Yan, Caijie;Wu, Chengyue;Han, Feng;Shen, Manman;Sun, Yiwei;Wang, Liyan;Zheng, Haoqin;Wang, Mengdong;Zhang, Zhendong;Sun, Liumei;Li, Duo;Yan, Caijie;Wu, Chengyue;Han, Feng;Shen, Manman;Sun, Yiwei;Wang, Liyan;Zheng, Haoqin;Wang, Mengdong;Zhang, Zhendong;Bo, Zongyi;Zhang, Zhendong;Bo, Zongyi;Zhang, Zhendong

作者机构：

关键词： PEDV; Spike gene; phylogenetic analysis; recombination analysis; antigenic analysis

期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.0 ）

ISSN： 2076-2615

年卷期： 2024 年 14 卷 15 期

页码：

收录情况： SCI

摘要： Simple Summary Simple Summary: Porcine epidemic diarrhea virus (PEDV) is a significant pathogen that has resulted in substantial economic ramifications within the worldwide swine industry. Since 2010, the emergence of novel variants of PEDV has been ongoing, resulting in frequent reclassification of PEDV strains in China. In this investigation, we found the emergence of nine variants in East Central China during 2020-2023. The S protein of three variants was likely derived from recombination of parental variants with a donor variant. There are novel mutations on amino acid 141-148 and these resulted in changes in antigenicity in the three variants. This research has the potential to serve as a basis for the development of a vaccine for PEDV.Abstract Porcine epidemic diarrhea virus (PEDV) is a major causative pathogen of a highly contagious, acute enteric viral disease. This study evaluated the emergence of nine variants in Jiangsu and Anhui provinces of China from 2020 to 2023. S gene-based phylogenetic analysis indicated that three variants belong to the G1c subgroup, while the other six strains are clustered within the G2c subgroup. Recombination analyses supported that three variants of the G1c subgroup were likely derived from recombination of parental variants FR0012014 and a donor variant AJ1102. In addition, there are novel mutations on amino acid 141-148 and these likely resulted in changes in antigenicity in the three variants. These results illustrated that the study provides novel insights into the epidemiology, evolution, and transmission of PEDV in China.

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