N6-Methyladenosine Modification-Related Genes Express Differentially in Sterile Male Cattle-Yaks

文献类型： 外文期刊

第一作者： Liu, Yuxin

作者： Liu, Yuxin;Chen, Lili;Ma, Yi;Liu, Yuxin;Chen, Lili;Ma, Yi;Chen, Lili;Ma, Yi;Jiang, Hui;Wang, Hongzhuang;Zhang, Yujiao;Yuan, Zhengrong

作者机构：

关键词： yak; cattle-yak; male sterility; m(6)A modification; m(6)A-related genes

期刊名称：LIFE-BASEL （ 影响因子：3.4； 五年影响因子：3.4 ）

ISSN：

年卷期： 2024 年 14 卷 9 期

页码：

收录情况： SCI

摘要： N-6-methyladenosine (m(6)A), an RNA post-transcriptional modification, plays a crucial role in spermatogenesis. Cattle-yaks are interspecific hybrid offsprings of yak and cattle, and male cattle-yaks are sterile. This study aims to investigate the role of m(6)A modification in male cattle-yak infertility. Herein, testicular tissues were analyzed via histological observations, immunohistochemical assays, reverse-transcription quantitative polymerase chain reaction, Western blotting, and immunofluorescence assays. The results revealed that male cattle-yaks presented smaller testes (5.933 +/- 0.4885 cm vs. 7.150 +/- 0.3937 cm), with only single cell layers in seminiferous tubules, and weakened signals of m(6)A regulators such as METTL14 (methyltransferase-like 14), ALKBH5 (alpha-ketoglutarate-dependent hydroxylase homolog 5), FTO (fat mass and obesity-associated protein), and YTHDF2 (YTH N-6-methyladenosine RNA binding protein F2), both at the RNA and protein levels, compared with those of yaks. Altogether, these findings suggest that m(6)A modification may play a crucial role in male cattle-yak sterility, providing a basis for future studies.

分类号：

  • 相关文献
作者其他论文 更多>>
  • Anti-Inflammatory potential of lactic acid bacteria for dairy cows during the periparturient period

    作者：Ma, Yi;Feng, Yong;Chen, Yong;Chen, Huayou;Gao, Xingliang;Liu, Fuyuan;Cheng, Long;Li, Zelin;Elsabagh, Mabrouk

    关键词：Periparturient; Dairy cow; Inflammation; Lactic acid bacteria; Challenges

  • Investigating the influence of the molecular structure and physiochemical properties of starches from glutinous and japonica sorghum on light-flavor liquor fermentation

    作者：Ma, Zhenbing;Wang, Chenyang;Tian, Yuanyuan;Bian, Minghong;Ma, Yi;Lan, Haibo;Ma, Zhenbing;Wang, Chenyang;Tian, Yuanyuan;Bian, Minghong;Ma, Yi;Lan, Haibo;Zhao, Dong;Zheng, Jia;Su, Jian;Wang, Jiaxu;Ke, Fulai

    关键词：Sorghum starch; Fine structure; Pasting properties; Gelatinization properties; Thermal properties

  • Occurrence of Organophosphate Esters in Food and Food Contact Materials and Related Human Exposure Risks

    作者：Cui, Yajing;Zhou, Ruoxian;Zhang, Aiqian;Fu, Jianjie;Cui, Yajing;Zhang, Aiqian;Fu, Jianjie;Zhou, Ruoxian;Yin, Yuhan;Liu, Yuxin;Zhao, Nannan;Li, Hongting;Li, Xiaomin

    关键词：organophosphateesters; food contact materials; food; humanexposure; migration

  • Adaptation mechanisms of Brucella abortus to low magnesium ion stress

    作者：Wang, Hengtai;Lv, Lang;Huang, Yike;Jiang, Hui;Yang, Xiaowen;Ding, Jiabo;Li, Peng;Zhu, Liangquan;Xu, Lei;Wang, Nan;Sang, Huaiming;Jiang, Jianxia

    关键词：Brucella abortus; Low Mg2+; Transcriptome analysis; MgtC; HP3

  • Deciphering the Population Characteristics of Leiqiong Cattle Using Whole-Genome Sequencing Data

    作者：Guo, Yingwei;Ge, Fei;Lyu, Chenxiao;Liu, Yuxin;Li, Junya;Chen, Yan;Zhao, Zhihui;Yu, Haibin;Lyu, Chenxiao

    关键词：population genetics; genomic characteristics; Leiqiong cattle; selective sweep

  • The nature of complex structural variations in tomatoes

    作者：Cui, Xue;Liu, Yuxin;Zhao, Qiyue;Liu, Yang;Chen, Xiuling;Liu, Jiayin;Chen, Xu;Ghanizadeh, Hossein;Wang, Aoxue;Sun, Miao;Yin, Hang;Zhou, Yao;Huang, Yicheng;Zhang, Jianwei;Huang, Yicheng;Yao, Qiulin;Zhang, Huixin;Mo, Fulei;Zhang, Yao;Qiu, Youwen;Feng, Mingfang;Zhong, Hongbin;Zhou, Yao

    关键词：

  • EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research

    作者：Bai, Defeng;Xun, Jiani;Ma, Chuang;Luo, Hao;Yang, Haifei;Hou, Huiyu;Lv, Hujie;Wan, Xiulin;Wang, Yao;Yousuf, Salsabeel;Zeng, Meiyin;Zhang, Tianyuan;Gao, Yunyun;Liu, Yong-Xin;Chen, Tong;Ma, Chuang;Yang, Haifei;Cao, Chen;Cao, Xiaofeng;Cui, Jianzhou;Deng, Yuan-Ping;Deng, Zhaochao;Yu, Hao;Zhang, Chunfang;Dong, Wenxin;Dong, Wenxue;Du, Juan;Fang, Qunkai;Fang, Wei;Fang, Yue;Luan, Yaning;Fu, Fangtian;Fu, Min;Fu, Yi-Tian;Gao, He;Ge, Jingping;Guo, Yuhao;Gong, Qinglong;Lou, Wenbo;Gu, Lunda;Yang, Li;Guo, Peng;Hai, Tang;Liu, Hao;He, Jieqiang;He, Zi-Yang;Huang, Can;Ji, Shuai;Jiang, ChangHai;Jiang, Gui-Lai;Jiang, Lingjuan;Jin, Ling N.;Li, Changchao;Kan, Yuhe;Kang, Da;Kou, Jin;Lam, Ka-Lung;Li, Chong;Li, Fuyi;Li, Liwei;Li, Miao;Li, Xin;Li, Ye;Li, Zheng-Tao;Zhu, Chengshuai;Liang, Jing;Mo, Jiayuan;Lin, Yongxin;Liu, Changzhen;Liu, Danni;Zhang, Jing;Chen, Shifu;Liu, Fengqin;Liu, Jia;Liu, Tianrui;Liu, Tingting;Wang, Xinlong;Liu, Xinyuan;Luo, Yuanyuan;Liu, Yaqun;Liu, Bangyan;Liu, Minghao;Lv, Hujie;Ma, Tengfei;Mai, Zongjiong;Niu, Dongze;Pan, Zhuo;Qi, Heyuan;Shi, Zhanyao;Song, Chunjiao;Sun, Fuxiang;Sun, Yan;Tian, Sihui;Wang, Guoliang;Wang, Hongyang;Wang, Hongyu;Wang, Huanhuan;Wang, Jing;Wang, Jun;Wang, Kang;Wang, Leli;Yao, Xiaofang;Wang, Shao-kun;Xiao, Zufei;Xing, Huichun;Xu, Yifan;Yang, Song;Yan, Shu-yan;Zhang, Yi-Bo;Yang, Yuanming;Lei, Yu;Yuan, Zhengrong;Zhang, Chunge;Zhang, Huimin;Zhang, Na;Zhang, Yupeng;Zhang, Zheng;Zhou, Mingda;Zhou, Yuanping;Zhu, Zhihao;Zhu, Lin;Zhu, Yue;Zou, Hongqin;Zuo, Anna;Dong, Wenxuan;Wen, Tao;Chen, Shifu;Chen, Shifu;Li, Guoliang

    关键词：metagenome; microbiome; microbiota; pipeline; visualization

微信小程序