Joint toxicity mechanisms of binary emerging PFAS mixture on algae (Chlorella pyrenoidosa) at environmental concentration

文献类型： 外文期刊

第一作者： Liu, Xianglin

作者： Liu, Xianglin;Zheng, Xiaowei;Zhang, Liangliang;Fan, Zhengqiu;Li, Yanyao;Huang, Honghui;Huang, Honghui

作者机构：

关键词： Inhibition effect; Toxicity; Synergetic effect; Transcriptome; Biological pathway

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：14.224； 五年影响因子：12.984 ）

ISSN： 0304-3894

年卷期： 2022 年 437 卷

页码：

收录情况： SCI

摘要： Since traditional Per-and polyfluoroalkyl substances (PFAS) were banned in 2009 due to their bioaccumulation, persistence and biological toxicity, the emerging PFAS have been widely used as their substitutes and entered the aquatic environment in the form of mixtures. However, the joint toxicity mechanisms of these emerging PFAS mixtures to aquatic organisms remain largely unknown. Then, based on the testing of growth inhibition, cytotoxicity, photosynthesis and oxidative stress, and the toxicity mechanism of PFAS mixture (Perfluorobutane sulfonate and Perfluorobutane sulfonamide) to algae was explored using the Gene set enrichment analysis (GSEA). The results revealed that all three emerging PFAS treatments had a certain growth inhibitory effect on Chlorella pyrenoidosa (C. pyrenoidosa), but the toxicity of PFAS mixture was stronger than that of individual PFAS and showed a significant synergistic effect at environmental concentration. The joint toxicity mechanisms of binary PFAS mixture to C. pyrenoidosa were related to the damage of photosynthetic system, obstruction of ROS metabolism, and inhibition of DNA replication. Our findings are conductive to adding knowledge in understanding the joint toxicity mechanisms and provide a basis for assessing the environmental risk of emerging PFAS.

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