Structural identification and antioxidative activity evaluation of flaxseed lignan macromolecules: structure-activity correlation

文献类型： 外文期刊

第一作者： Cheng, Chen

作者： Cheng, Chen;Wang, Lei;Yu, Xiao;Huang, Fenghong;Yang, Jing;Xia, Xiaoyang;Xiang, Xia;Deng, Qianchun;Cheng, Chen;Wang, Lei;Yu, Xiao;Huang, Fenghong;Yang, Jing;Xia, Xiaoyang;Xiang, Xia;Deng, Qianchun;Yu, Xiao;Geng, Fang;Xu, Shufang

作者机构：

关键词： Flaxseed lignan macromolecules; Composition structure; Antioxidative activity; Structure-activity; Correlation

期刊名称：FOOD SCIENCE AND HUMAN WELLNESS （ 影响因子：7.4； 五年影响因子：7.8 ）

ISSN：

年卷期： 2024 年 13 卷 6 期

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收录情况： SCI

摘要： Flaxseed lignan macromolecules (FLM) are a class of important secondary metabolites in flaxseed, which have been widely concerned due to their biological and pharmacological properties, especially for their antioxidative activity. For the composition and structure of FLM, our results confirmed that ferulic acid glycoside (FerAG) was directly ester-linked with herbacetin diglucoside (HDG) or pinoresinol diglucoside (PDG), which might determine the beginning of FLM biosynthesis. Additionally, p-coumaric acid glycoside (CouAG) might determine the end of chain extension during FLM synthesis in flaxseed. FLM exhibited higher antioxidative activity in polar systems, as shown by its superior 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging capacity compared to the 2,2'-azinobis(3-ehtylbenzothiazolin-6-sulfnic acid) (ABTS) cation free radical scavenging capacity in non-polar systems. Moreover, the antioxidative activity of FLM was found to be highly dependent on its composition and structure. In particular, it was positively correlated with the number of phenolic hydroxyl groups (longer FLM chains) and inversely related to the steric hindrance at the ends (lower levels of FerAG and CouAG). These findings verified the potential application of FLM in nonpolar systems, particularly in functional food emulsions. (c) 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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