An Overview of Zika Virus and Zika Virus Induced Neuropathies

文献类型： 外文期刊

第一作者： Wahaab, Abdul

作者： Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Mustafa, Bahar E.;Mustafa, Bahar E.;Tawaab, Abdul;Hameed, Muddassar;Hameed, Muddassar;Hameed, Muddassar;Batool, Hira;Shoaib, Anam;Wei, Jianchao

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关键词： neurotropic flaviviruses; zika virus; neuropathies; transmission; neuropathogenesis; prevention; vaccines; treatment; antivirals; mosquito/vector control; oncolytic; animal and cell models

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）

ISSN： 1661-6596

年卷期： 2025 年 26 卷 1 期

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收录情况： SCI

摘要： Flaviviruses pose a major public health concern across the globe. Among them, Zika virus (ZIKV) is an emerging and reemerging arthropod-borne flavivirus that has become a major international public health problem following multiple large outbreaks over the past two decades. The majority of infections caused by ZIKV exhibit mild symptoms. However, the virus has been found to be associated with a variety of congenital neural abnormalities, including microcephaly in children and Guillain-Barre syndrome in adults. The exact prediction of the potential of ZIKV transmission is still enigmatic and underlines the significance of routine detection of the virus in suspected areas. ZIKV transmission from mother to fetus (including fetal abnormalities), viral presence in immune-privileged areas, and sexual transmission demonstrate the challenges in understanding the factors governing viral persistence and pathogenesis. This review illustrates the transmission patterns, epidemiology, control strategies (through vaccines, antivirals, and vectors), oncolytic aspects, molecular insights into neuro-immunopathogenesis, and other neuropathies caused by ZIKV. Additionally, we summarize in vivo and in vitro models that could provide an important platform to study ZIKV pathogenesis and the underlying governing cellular and molecular mechanisms.

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