Pharmacokinetics and relative bioavailability study of two cefquinome sulfate intramammary infusions in cow milk

文献类型： 外文期刊

第一作者： Li, Shuang

作者： Li, Shuang;Yu, Na;Tang, Yaoxin;Liu, Chunshuang;Zhang, Ying;Chen, Xiaojie;Li, Xiubo;Liu, Yiming;Li, Shuang;Li, Shuang;Yu, Na;Tang, Yaoxin;Liu, Chunshuang;Zhang, Ying;Chen, Xiaojie;Li, Xiubo;Liu, Yiming;Yu, Na;Tang, Yaoxin;Liu, Chunshuang;Zhang, Ying;Chen, Xiaojie;Li, Xiubo;Liu, Yiming;Wu, Hao

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关键词： pharmacokinetics; relative bioavailability; UPLC-MS/MS; cefquinome sulfate intramammary infusion; cow milk

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.2； 五年影响因子：3.5 ）

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年卷期： 2024 年 11 卷

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收录情况： SCI

摘要： In this study, two intramammary infusions of cefquinome sulfate were investigated for pharmacokinetics and bioavailability. Twelve lactating cows for each group were administered an effective dose of 75 mg/gland for cefquinome, with milk samples collected at various time intervals. The concentrations of cefquinome in milk at different times were determined by the UPLC-MS/MS method. Analyses of noncompartmental pharmacokinetics were conducted on the concentration of cefquinome in milk. Mean pharmacokinetic parameters of group A and group B following intramammary administration were as follows: AUClast 300558.57 +/- 25052.78 ng/mL and 266551.3 +/- 50654.85 ng/mL, Cmax 51786.35 +/- 11948.4 ng/mL and 59763.7 +/- 8403.2 ng/mL, T1/2 5.69 +/- 0.62 h and 5.25 +/- 1.62 h, MRT 7.43 +/- 0.79 h and 4.8 +/- 0.78 h, respectively. Pharmacokinetic experiments showed that the relative bioavailability of group B was 88.69% that of group A. From our findings, group B (3 g: 75 mg) shows a quicker drug elimination process than group A (8 g: 75 mg), which suggests that the withdrawal period for the new formulation may be shorter.

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