Phytochemical and toxicological evaluations ofProsopis africana(GUILL. and PERR.) extract on albino wistar rats

文献类型： 外文期刊

第一作者： Obode, Okukwe Christa

作者： Obode, Okukwe Christa;Adebayo, Abiodun Humphrey;Obode, Okukwe Christa;Li, Chunyang

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关键词： Medicinal plants; Prosopis africana; Toxicity; Phytochemicals; Wistar rats

期刊名称：TOXICOLOGICAL RESEARCH （ 影响因子：3.019； 五年影响因子：3.188 ）

ISSN： 1976-8257

年卷期： 2021 年 37 卷 2 期

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收录情况： SCI

摘要： In this study, we investigated the phytochemical and toxicological impacts of the ethanol leaf extract ofProsopis africanain albino rats. Preliminary phytochemical analysis was done using established methods. Acute and 28-day sub-chronic toxicity evaluations of the extract were carried out in wistar rats. Five groups made up of 8 rats per group were used and treated with 500, 1000, 1500 and 2000 mg/kg b.wt. respectively; while the control group received 1 ml of 10% Tween-20 solution. Phytochemicals detected include tannins, saponins, flavonoids, alkaloids, anthocyanin, quinones, terpenoids and steroids. There were no signs of toxicity in the acute toxicity study neither was any death recorded. Weight loss and death were recorded after 18 days of treatment in groups treated with 1500 and 2000 mg/kg b.wt. No significant alteration of haematological parameters was observed, however increased WBC count was recorded. Liver and kidney function parameters were significantly (p < 0.05) reduced, while significant (p < 0.05) increase in triglycerides with lowered cholesterol was seen when compared with the control group. Histological evaluations of the liver, kidney, heart and testicular tissues revealed normal sections in majority of the animals; however, mild vascular congestions were observed at random doses (liver and heart at 1500 mg/kg b.wt.; kidney at 500 mg/kg b.wt.). Our study shows that ethanol leaf extract ofP. africanawould probably not cause significant toxic effects as indicated by haematological and biochemical parameters. However, there may be need to apply caution in its use at high doses given that death occurred at 1500 mg/kg b.wt. during the repeat-dose toxicity study.

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