Structure characterization and protective effect against UVB irradiation of polysaccharides isolated from the peach gums

文献类型： 外文期刊

第一作者： Zhang, Yi

作者： Zhang, Yi;Si, Haoyu;Wang, Xiao;Wu, Songheng;Chen, Bingjie;Qiao, Yongjin;Zheng, Shilian;Guo, Qingbin;Liu, Yanfang;Xie, Fan;Zhang, Yi;Zhai, Chuntao

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关键词： Peach gum polysaccharide; Structure; UVB; Anti-photoaging activity

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 311 卷

页码：

收录情况： SCI

摘要： Peach gum polysaccharides (PGPs) have attracted increasing attention for their potential biological properties and application in the food and cosmetic industries. This study aimed to investigate the structural characteristics and anti-photoaging activity of PGPs. The purification of PGPs resulted in two polysaccharides (PGP-1 and PGP2). Results showed that PGP-1 and PGP-2 had a molecular weight of 4515.31 kDa and 15.02 kDa, respectively. Their structures were elucidated via GC-MS and NMR spectrum and proved to be an arabinogalactan. In addition, PGP-1 and PGP-2 do not have mucous-membrane irritation on chicken embryo CAM. Mainly, PGP-1 (1.5 mg/mL) significantly inhibits the expressions of MMPs (MMP-1, MMP-3, and MMP-12) in the UVB-induced human immortalized epidermal cells (HaCaT), indicating that PGP-1 could reduce collagen loss caused by UVB irradiation. PGP-1 also can inhibit cell senescence and apoptosis by reducing p16, p21, and p53 protein expressions. Based on these findings, our data suggested that PGPs may be used to develop effective natural antiphotoaging ingredients to promote skin health.

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