Intestinal organoid technology and applications in probiotics

文献类型： 外文期刊

第一作者： Tan, Han

作者： Tan, Han;Chen, Xiaoyong;Wang, Chen;Song, Jiajia;Xu, Jiahui;Suo, Huayi;Chen, Xiaoyong;Wang, Chen;Song, Jiajia;Suo, Huayi;Chen, Xiaoyong;Wang, Chen;Song, Jiajia;Suo, Huayi;Chen, Xiaoyong;Wang, Chen;Song, Jiajia;Suo, Huayi;Zhang, Yuhong

作者机构：

关键词： Intestinal organoid; probiotic; intestinal health; probiotic mechanisms; intestinal microbiota

期刊名称：CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION （ 影响因子：10.2； 五年影响因子：11.8 ）

ISSN： 1040-8398

年卷期： 2023 年

页码：

收录情况： SCI

摘要： The impacts of probiotics on maintaining the host's intestinal health have been extensively confirmed. Organoid technology revolutionizes intestinal health research by providing a unique platform to study the effects of probiotics. It overcomes challenges posed by animal models and 2D cell models in accurately simulating the in vivo environment. This review summarizes the development of intestinal organoid technology and its potential applications in intestinal health research as well as highlights the regulatory mechanisms of probiotics on intestinal health, which have been revealed using intestinal organoid technology. Furthermore, an overview of its potential applications in probiotic research has also been provided. This review aims to improve the understanding of intestinal organoid technology's applications in this field as well as to contribute to its further development. [GRAPHICS] .

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