Cationic fructan-based pH and intestinal flora dual stimulation nanoparticle with berberine for targeted therapy of IBD

文献类型： 外文期刊

第一作者： Li, Hongyu

作者： Li, Hongyu;Yang, Wenna;Tian, Luyao;Zhang, Weimei;Tian, Hongyue;Liang, Xu;Li, Xia;Gao, Wenyuan;Huang, Luqi;Guo, Lanping;Wu, Xiongzhi;Li, Hongyu;Li, Xia;Gao, Wenyuan

作者机构：

关键词： Ulcerative colitis; Berberine; pH and intestinal flora dual response; Fructan; Nanoparticles

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2024 年 256 卷

页码：

收录情况： SCI

摘要： Inflammatory bowel disease (IBD) can cause intestinal microbial imbalance and aggravate intestinal inflammation. Mixed fructan is more easily fermented by colonic microorganisms and can be used as colonic drug delivery materials. Here, we constructed a mixed fructan based nanoparticle with dual targeted stimulation of pH and intestinal flora to effectively deliver berberine for the treatment of ulcerative colitis (UC). The complex of fructan based nanoparticle and berberine (BBRNPs) significantly ameliorated the inflammatory response of sodium dextran sulfate (DSS)-induced colitis in mice by inhibiting the activation of NF-kappa B/STAT-3 pathway and increasing tight junction protein expression in vivo. Importantly, BBRNPs improved the responsiveness of colitis microbiome and effectively regulated the relative homeostasis of harmful flora Enterobacteriaceae and Escherichia-shigolla, and beneficial flora Ruminococcaceae and Akkermansiaceae. This study provides a promising strategy for the effective treatment of UC and expands the application of branched fructan in pharmaceutics.

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