Development of purity certified reference materials to establish metrological traceability for the measurement of nitroimidazoles in agricultural products

文献类型： 外文期刊

第一作者： Jiang, Bin

作者： Jiang, Bin;Liu, Qingyi;Wang, Min;Yang, Mengrui;Li, Fukai;Zhang, Liyuan;Zhou, Jian

作者机构：

关键词： Nitroimidazole; Certified reference material; Metrological traceability; Uncertainty

期刊名称：ANALYTICAL AND BIOANALYTICAL CHEMISTRY （ 影响因子：3.8； 五年影响因子：3.8 ）

ISSN： 1618-2642

年卷期： 2024 年 416 卷 28 期

页码：

收录情况： SCI

摘要： It is of significant importance to public health that reliable monitoring of nitroimidazoles be conducted, while certified reference materials (CRMs) are essential for accurate and reliable detection. A project has been initiated with the objective of developing nitroimidazole purity CRMs to ensure that results from nationwide monitoring laboratories for nitroimidazoles in antibiotic residues can be compared and traced. The candidates were successively characterized in terms of their structure by means of infrared (IR) spectroscopy and mass spectrometry (MS). The mass balance (MB) method and the quantitative nuclear magnetic resonance (qNMR) method were utilized to determine the purity of nitroimidazoles with remarkable accuracy. Furthermore, a methodical investigation was conducted on homogeneity, stability, and uncertainty. Six nitroimidazole purity CRMs, including tinidazole (GBW09252), secnidazole (GBW09286), ronidazole (GBW09288), metronidazole (GBW(E)090755), dimetridazole (GBW(E)090819), and ornidazole (GBW(E)090820), were finally manufactured following authorization from China's State Administration for Market Regulation (SAMR). By using these CRMs, it is possible to improve the traceability, accuracy, and comparability of nitroimidazole measurements in a range of agricultural products, protecting public health.

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