An Aegilops longissima NLR protein with integrated CC-BED module mediates resistance to wheat powdery mildew

文献类型： 外文期刊

第一作者： Ma, Chao

作者： Ma, Chao;Li, Huanhuan;Liu, Wenxuan;Liu, Qianwen;Zhao, Yue;Tian, Xiubin;Chen, Xuexue;Ma, Shuyang;Zhao, Yusheng;Tian, Xiubin;Ma, Shuyang;Dong, Zhenjie;Cao, Aizhong;Yin, Guihong;Zhang, Liwei;Wang, Shiwei;Liu, Cheng;Yan, Hongfei;Sehgal, Sunish K.;Zhang, Zhibin;Liu, Bao

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）

ISSN：

年卷期： 2024 年 15 卷 1 期

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收录情况： SCI

摘要： Powdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), reduces wheat yields and grain quality, thus posing a significant threat to global food security. Wild relatives of wheat serve as valuable resources for resistance to powdery mildew. Here, the powdery mildew resistance gene Pm6Sl is cloned from the wild wheat species Aegilops longissima. It encodes a nucleotide-binding leucine-rich repeat (NLR) protein featuring a CC-BED module formed by a zinc finger BED (Znf-BED) domain integrated into the coiled-coil (CC) domain. The function of Pm6Sl is validated via mutagenesis, gene silencing, and transgenic assays. In addition, we develop a resistant germplasm harbouring Pm6Sl in a very small segment with no linkage drag along with the diagnostic gene marker pm6sl-1 to facilitate Pm6Sl deployment in wheat breeding programs. The cloning of Pm6Sl, a resistance gene with BED-NLR architecture, will increase our understanding of the molecular mechanisms underlying BED-NLR-mediated resistance to various pathogens.

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