Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway

文献类型： 外文期刊

第一作者： Du, Pengfei

作者： Du, Pengfei;Giri, Bikash R.;Fang, Chuantao;Cheng, Guofeng;Du, Pengfei;Xia, Tianqi;Li, Xuxin;Li, Shun;Cheng, Guofeng;Du, Pengfei;Yan, Shi;Cheng, Guofeng

作者机构：

期刊名称：COMMUNICATIONS BIOLOGY （ 影响因子：5.1； 五年影响因子：5.8 ）

ISSN：

年卷期： 2024 年 7 卷 1 期

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收录情况： SCI

摘要： Adult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling schistosomiasis. Here, we describe that Bantam miRNA and miR-1989 regulate Wnt signaling pathway by targeting Frizzled-5/7/9, which is involved in ovarian development and oviposition. Additionally, Frizzled-7 could cooperate with SjRho to maintain normal ovarian development and egg productions and SjRho may interact with Hsp60 to potentially support Frizzled-7 trafficking and signaling. Further in vivo inhibition of SjRho in mice model infected with Schistosoma results in a remarkable decrease in worm burden and egg productions. Our findings not only broaden the functions of Bantam miRNA and miR-1989 as well as Wnt signaling pathway, but also imply that interruption of Bantam/miR-1989-Frizzled-5/7/9-SjRho axis may serve as effective targets against schistosomiasis.

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