Identification, pathogenicity and molecular characterization of a novel fowl adenovirus 8b strain

文献类型： 外文期刊

第一作者： Song, Yapeng

作者： Song, Yapeng;Liu, Lin;Sun, Wenjie;Gao, Wenming;Song, Xiaonan;Wang, Yang;Huang, Zongmei;Li, Xinsheng;Wei, Qiang

作者机构：

关键词： fowl adenovirus; isolation; recombination; identification; pathogenicity

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 6 期

页码：

收录情况： SCI

摘要： Since 2012, there has been a noticeable upward trend in the global incidence of inclusion body hepatitis ( IBH ) cases, leading to substantial economic losses in the poultry industry. In response to this trend, the current study aimed to investigate the phylogenetic information, genetic mutations, and pathogenicity of the highly pathogenic fowl adenovirus ( FAdV ) strain HN1472, which was isolated from liver samples obtained from a laying flock affected by IBH. This investigation was carried out using 1-day-old specific pathogen-free ( SPF ) chickens. Recombination and phylogenetic analyses confirmed that HN1472 is a recombinant strain derived from FAdV-8a and FAdV-8b, and exhibited significant genetic divergence in the hexon, fiber, and ORF19 genes. Notably, the phylogenetic analysis identified recombination events in these regions. Furthermore, animal experiments revealed that HN1472 is a highly pathogenic isolate, causing 80% mortality and manifesting clinical signs of IBH in SPF chickens. Furthermore, the recombinant FAdV serotype 8b ( FAdV-8b ) was found to be widely distributed in various tissues, with a higher concentration in the livers and gizzard tissue at 3 d postchallenge ( dpc ). Collectively, these findings contribute to our current understanding of the factors influencing the pathogenicity and genetic diversity of FAdV serotype 8b ( FAdV-8b ) in China.

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