Performance Characterization and Antibacterial Activity of a Composite Hydrogel Composed of Oxidized κ-Carrageenan, Acrylamide, and Silver-Based Metal-Organic Frameworks

文献类型： 外文期刊

第一作者： Qi, Bo

作者： Qi, Bo;Li, Zhaoyu;Pan, Chuang;Zhao, Yongqiang;Long, Xiaoshan;Li, Chunsheng;Wang, Yueqi;Hu, Xiao;Wang, Di;Yang, Shaoling;Qi, Bo;Zhao, Yongqiang;Yang, Shaoling

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关键词： hydrogel; oxidized kappa-carrageenan; Ag-MOFs; characterization; antibacterial property; biocompatibility

期刊名称：GELS （ 影响因子：5.3； 五年影响因子：5.4 ）

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年卷期： 2025 年 11 卷 6 期

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收录情况： SCI

摘要： To advance seaweed polysaccharide applications in hydrogel wound dressings, five antibacterial composite hydrogels (groups A similar to E) were synthesized using oxidized kappa-carrageenan (OKC), acrylamide (AM), and progressively increasing concentrations of silver-based metal-organic frameworks (Ag-MOFs). Systematic characterization revealed concentration-dependent effects: (1) positive correlations were obtained for the moisture content (MC, maximized at 82.70% in E) and antibacterial efficacy (dose-dependent enhancement); (2) negative impacts were obtained for the swelling ratio (SR, E: 479% vs. A: 808%); and (3) high-dose drawbacks but low-dose benefits in terms of water resistance (WR), tensile strength (TS), elongation at break (EB), and microstructure were obtained. Group B demonstrated optimal Ag-MOFs loading, enhancing TS and EB, while excessive Ag-MOFs loading in C similar to E significantly degraded them (p < 0.05). Microstructural analysis showed severe 3D spatial damage in D similar to E. Furthermore, cytocompatibility assessments revealed that all groups maintained a cell viability exceeding 90%, demonstrating excellent biocompatibility. Among them, A similar to C showed a viability statistically equivalent to the control (p > 0.05) and were significantly higher than D similar to E (p < 0.05). In conclusion, group B emerged as the optimal Ag-MOFs formulation and exhibited superior WR, enhanced mechanical strength (TS and EB), and potent antibacterial activity while maintaining microstructural integrity and excellent biosafety. This Ag-MOFs/OKC/PAM hydrogel provides dual infection prevention and tissue support, maximizing seaweed polysaccharide benefits with excellent biocompatibility.

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