Riboflavin Deficiency and Apoptosis: A Review

文献类型： 外文期刊

第一作者： Zhang, Bo

作者： Zhang, Bo;Hou, Shuisheng;Tang, Jing;Zhang, Bo

作者机构：

关键词： riboflavin; apoptosis; mitochondrial pathway; endoplasmic reticulum stress; redox balance

期刊名称：JOURNAL OF NUTRITION （ 影响因子：3.8； 五年影响因子：4.2 ）

ISSN： 0022-3166

年卷期： 2025 年 155 卷 1 期

页码：

收录情况： SCI

摘要： Riboflavin, commonly known as vitamin B2, is an essential micronutrient critical for the function of flavoproteins, which utilize flavin mononucleotide and flavin adenine dinucleotide as cofactors in energy metabolism, lipid metabolism, redox regulation, and protein folding. Nutritional riboflavin deficiency (RD) has previously been observed in humans and animals, leading to adverse outcomes such as growth retardation, increased mortality, and liver damage, which may be attributed to apoptosis. Although such deficiencies are now uncommon because of improved living standards, certain high-risk groups (e.g. those with chronic diseases, the elderly, and pregnant) have increased riboflavin demands, making them vulnerable to physiological RD associated with apoptosis. Understanding the pathways through which RD induces apoptosis, including mitochondrial dysfunction, endoplasmic reticulum stress, and reactive oxygen species, is essential for grasping its broader health impacts. Additionally, this deficiency disrupts fatty acid metabolism, potentially resulting in lipotoxic apoptosis. Despite its significance, RD-induced apoptosis remains underexplored in the literature. Therefore, this review will discuss the roles of redox imbalance, mitochondrial dysfunction, endoplasmic reticulum stress, and lipotoxicity in apoptosis regulation because of RD, aiming to highlight its importance for improving riboflavin nutrition and overall health.

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