文献类型： 外文期刊
第一作者： Zhang, Yeshun
作者： Zhang, Yeshun;Chen, Heguang;Yan, Hui;Xiong, Meng;Zhang, Guozheng;Zhang, Yeshun;Chen, Heguang;Yan, Hui;Xiong, Meng;Zhang, Guozheng;Wu Tangfeng;Zhang, Yeshun;Shen, Congyi;Chen, Heguang;Yan, Hui;Xiong, Meng;Zhang, Guozheng;Xu, Gang
作者机构：
关键词： Tissue engineering; Native sericin; Hydrogel; Robustness; Fibroin-deficient silkworm
期刊名称：FIBERS AND POLYMERS （ 影响因子：2.347； 五年影响因子：2.428 ）
ISSN： 1229-9197
年卷期： 2022 年 23 卷 7 期
页码：
收录情况： SCI
摘要： Sericin hydrogels with a serial of excellent properties are attractive in tissue engineering but still limited due to their poor mechanical strength. In this study we report a robust sericin hydrogel with high elastic modulus (310 kPa) that was formed by a native sericin solution with high concentration (16 %, w/v) collected from silkworm bodies. The hydrogel was performed via H2O2 and presented gelling kinetics within 30 s. This hydrogel possesses eximious elasticity, good cytocompatibility, and more stable in solution as well as porous structure. In addition, the hydrogel system is suitable for loading bioactive molecules owing to its wonderful sustained manner for delivering bioactive reagent. Together, our study indicates that the sericin hydrogel may serve as a new multifunctional platform for extending the application of sericin in tissue engineering and regenerative medicine.
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