Transcriptomics-based investigation of resistance differences to swine fever between large white pigs and min pigs

文献类型： 外文期刊

第一作者： Li, Jia

作者： Li, Jia;Meng, Xiangxu;Sheng, Xihui;Li, Jia;Ren, Deming;He, Yiyun;Wang, Lixian;Wang, Ligang

作者机构：

关键词： Min pigs; Large white pigs; Immune system; lncRNAs; mRNAs

期刊名称：VIRUS RESEARCH （ 影响因子：2.7； 五年影响因子：3.0 ）

ISSN： 0168-1702

年卷期： 2025 年 353 卷

页码：

收录情况： SCI

摘要： The genetic foundations underlying the observed disease resistance in certain indigenous pig breeds, notably the Min pigs of China, present a compelling underexplored subject of study. Exploring the mechanisms of disease resistance in these breeds could lay the groundwork for genetic improvements in pig immunity, potentially augmenting overall pig productivity. In this study, whole blood samples were collected from pre- and post- swine fever vaccinated Min and Large White pigs for transcriptome sequencing. The mRNA and lncRNA in both pig breeds were analyzed, and intra-group and inter-group comparisons were also conducted. The results indicated that a greater number of immune-related pathways such as the JAK-STAT and PI3K-AKT signaling were enriched in Min pigs. Furthermore, genes involved in inflammation and antiviral responses, including IL16, IL27, USP18, and DHX58, were upregulated in post-vaccination Min pigs compared to post-vaccination Large White pigs. This heightened immune responsiveness could contribute to the observed differences in disease resistance between Min pigs and Large White pigs.

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