Effects of Dietary Protein and Calcium on Thymus Apoptosis Induced by Fluoride in Female Rats (Wistar Rats)

文献类型： 外文期刊

第一作者： Wang, Hongwei

作者： Wang, Hongwei;Zhou, Bianhua;Cao, Jinling;Cao, Chunfang;Wang, Jundong;Zhou, Bianhua;Gu, Xinli

作者机构：

关键词： dietary calcium;dietary protein;fluoride;apoptosis;thymus;caspase

期刊名称：ENVIRONMENTAL TOXICOLOGY （ 影响因子：4.119； 五年影响因子：3.404 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Our previous studies showed that excessive fluoride (F) ingestion seriously damaged the nonspecific immune function in rabbits. However, the underlying mechanisms of the F-induced damage to the immune system are unclear. The purpose of this study was to investigate whether F induces thymus apoptosis in female rats and its underlying mechanisms by monitoring ultrastructural changes and DNA fragmentation. The results showed that excessive F induced ultrastructural changes and significantly increased the tail length and tailing ratio in thymus lymphocytes. Protein (Pr) supplementation markedly decreased the tailing ratio in thymus lymphocytes in the case of malnutrition. Furthermore, molecular analysis showed that excessive F ingestion significantly up-regulated the expression levels of caspase-3 and caspase-9 mRNA, whereas Pr and calcium (Ca) supplementation down-regulated the expression levels induced by excessive F in the case of malnutrition. In conclusion, these results indicate that excessive F up-regulates the expression levels of caspase-3 and caspase-9 mRNA and induces thymus apoptosis in female rats. Pr and Ca play key roles in process of F-induced thymus apoptosis in malnourished female rats.

分类号： R9

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