Antiinflammatory mechanisms of barley-based functional foods beyond diabetes management

文献类型： 外文期刊

第一作者： Din Ahmed, Hafiz Ghulam Muhu

作者： Din Ahmed, Hafiz Ghulam Muhu;Noor Shah, Adnan;Ahtasham Mushtaq, Muhammad;Yang, Xiaomeng;Yang, Jiazhen;Li, Xia;Yang, Li'e;Pu, Xiaoying;Zeng, Yawen;Din Ahmed, Hafiz Ghulam Muhu;Noor Shah, Adnan;Ahtasham Mushtaq, Muhammad

作者机构：

关键词： Barley; human; health; diabetic; food; antiinflammatory

期刊名称：TURKISH JOURNAL OF AGRICULTURE AND FORESTRY （ 影响因子：3.0； 五年影响因子：2.2 ）

ISSN： 1300-011X

年卷期： 2025 年 49 卷 3 期

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收录情况： SCI

摘要： This review article investigated the antiinflammatory properties of barley, emphasizing its benefits beyond diabetes management. Barley, historically valued for its nutritional and medicinal properties, is rich in bioactive compounds such as betaglucans, phenolic acids, and flavonoids. These compounds are known for their significant antioxidant and antiinflammatory activities. This study highlights the multifaceted mechanisms through which barley reduces systemic inflammation, including the enhancement of gut microbiota composition, the production of beneficial short-chain fatty acids, and the modulation of immune responses. Betaglucans in barley lower cholesterol, and regulate glucose levels, while phenolic acids and flavonoids inhibit proinflammatory enzymes and cytokines, thereby reducing oxidative stress and inflammation. Barley has been shown to effectively decrease inflammatory markers such as tumor necrosis factor-alpha and resistin, improves insulin sensitivity, and enhances glycemic control. Barley extracts show promising results in lowering proinflammatory cytokines and nitric oxide production, indicating their potential in managing various inflammatory conditions. Additionally, barley sprouts and leaves are rich in phenolic and flavonoids, which further contribute to their antiinflammatory effects by suppressing the expression of inflammatory cytokines and enzymes. The implications for public health are significant. Incorporating barley into the diet as a functional food offers a natural strategy to combat chronic inflammation and related diseases, including cardiovascular diseases, obesity, and cancer. Future research should aim to identify the specific bioactive components responsible for these effects, assess their bioavailability, and validate these findings through well-designed clinical trials in diverse human populations. Understanding the optimal forms and dosages of barley will enhance its therapeutic applications. This study provides a foundation for further exploration and development of barley-based functional foods and supplements aimed at mitigating inflammation-related conditions, thereby improving overall health outcomes. These findings align well with current nutritional guidelines that emphasize the importance of whole grains and fiber-rich foods in a balanced diet.

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