Flower-like mesoporous silica nanoparticles as an antigen delivery platform to promote systemic immune response

文献类型： 外文期刊

第一作者： Hou, Fengping

作者： Hou, Fengping;Teng, Zhidong;Ru, Jiaxi;Liu, Haiyun;Li, Jiajun;Zhang, Yun;Sun, Shiqi;Guo, Huichen;Hou, Fengping;Guo, Huichen;Hou, Fengping

作者机构：

关键词： Virus-like particles; Mesoporous silica nanoparticles; Cellular uptake; Immune response; Immunization route

期刊名称：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE （ 影响因子：6.458； 五年影响因子：7.096 ）

ISSN： 1549-9634

年卷期： 2022 年 42 卷

页码：

收录情况： SCI

摘要： Virus-like particles (VLPs), a kind of superior subunit vaccine, are assembled from the viral structural proteins with similar capsids to viruses. However, the efficiency of cell uptake is not satisfactory. We prepared flower-like mesoporous silica nanoparticles (SiNPs) with large pore channels and interior cavities to solve the problem. The highly loaded VLPs-SiNPs composites not only enhanced the stability of VLPs, but also delivered antigen to cells and improved the cellular uptake efficiency. Compared with naked VLPs, mice intramuscularly immunized with the VLPs-SiNPs composite induced higher specific antibodies, greater lymphocyte activation and higher level of cytokine secretion. Moreover, the VLPs-SiNPs composite as vaccine also promoted mucosal immune response through intranasal immune pathway. Therefore, the VLPs-SiNPs enable to induce strong cellular, humoral, and slight mucosal immune response through different immunization routes. These results are potentially useful for vaccine formulations and may provide further reference for vaccine design and delivery systems. (c) 2022 Elsevier Inc. All rights reserved.

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