Flax lignans regulate the conversion of α-linolenic acid into n-3 LCPUFAs in mice ingesting sunflower phospholipid-stabilized nanoemulsions
文献类型： 外文期刊
第一作者： Wang, Lei
作者： Wang, Lei;Yu, Xiao;Cheng, Chen;Xu, Jiqu;Xiang, Xia;Deng, Qianchun;Yu, Xiao;Tang, Xiaoqiao
作者机构：
关键词：
Flax lignans; Nanoemulsions;
期刊名称：FOOD SCIENCE AND HUMAN WELLNESS （ 影响因子：7.4； 五年影响因子：7.8 ）
ISSN：
年卷期： 2025 年 14 卷 8 期
页码：
收录情况： SCI
摘要： Dietary supplementation with plant-derived alpha-linolenic acid (ALA) has the potential to alleviate the insufficient intake of global n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs), but faces the bottleneck of high beta-oxidation consumption, oxidative susceptibility, and low conversion efficiency. The current study investigated how flax lignans with different degrees of polymerization and glycosylation affect the conversion of ALA to n-3 LCPUFAs in mice over 35 days of administering sunflower phospholipid-stabilized flaxseed oil nanoemulsions. Results showed that flax lignan macromolecules (FLM) increased hepatic protein expression of elongase of very long chain fatty acid 5 (Elovl5, 24.2%) and fatty acid desaturase 2 (Fads2, 44.7%), thereby positively regulating ALA conversion pathways and raising serum eicosapentaenoic acid (EPA) levels (52.7%) via liver lipid re-efflux. Secoisolariciresinol diglucoside (SDG) enhanced ALA desaturation by upregulating hepatic protein expression of Fads1 (30.4%) and Fads2 (45.6%), increasing serum EPA levels (55.9%) and hepatic docosahexaenoic acid (DHA) levels (10%). Secoisolariciresinol (SECO) elevated hepatic protein expression of Elovl2 (30.7%), Elovl5 (11.7%), Fads1 (37.9%), and Fads2 (24.1%), but also increased carnitine palmitoyltransferase 1a (45.2%), leading to decreased ALA, EPA, and DHA levels in serum and liver. Therefore, in comparison, FLM and SDG emerge as the dominant structural units that positively regulate the conversion of ALA. These findings lay a groundwork for designing precise dietary delivery systems to enhance the conversion to n-3 LCPUFAs.
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