Metabolic profiling and evaluation of antioxidant and anti-inflammatory properties of Apis cerana cerana Honey from Sansha City, Hainan Province, China

文献类型： 外文期刊

第一作者： Wu, Jiao

作者： Wu, Jiao;Xu, Xiang-Tan;Xing, Cheng;Zhao, Shan;Gao, Jing-Lin;Wang, Shi-Jie;Hao, Xin-Bao;Fang, Xing-Yue;Xie, Zhi-Hao;Xu, Lu;Xu, Xiang-Tan;Xing, Cheng

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关键词： Apis cerana cerana honey; Metabolic profile; Antioxidant activity; Anti-inflammatory activity

期刊名称：FOOD CHEMISTRY （ 影响因子：9.8； 五年影响因子：9.7 ）

ISSN： 0308-8146

年卷期： 2025 年 475 卷

页码：

收录情况： SCI

摘要： Honey has been recognized for its role in disease prevention through nutritional modulation. In this study, we comprehensively assessed the physicochemical parameters, metabolic profile, antioxidant and anti-inflammatory activities of multifloral honeys produced by Apis cerana cerana in Sansha City (SS), Hainan Province. Metabolomic analysis identified SS honey had multiple bioactive compounds known for antioxidant and antiinflammatory properties. Compared to A. cerana cerana honey from central regions of Hainan Province, SS honey showed higher levels of TFC (113.80 mg RE/100 g) and TPC (45.86 mg GAE/100 g). Furthermore, SS honey demonstrated greater antioxidant activity, as evidenced by FRAP (1503.16 mu mol TE/kg), DPPH IC50 (33.59 mg/mL), and ABTS IC50 (11.03 mg/mL). SS honey significantly reduced the levels of cyclooxygenase-2 (COX-2), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and tumor necrosis factor-alpha (TNF-alpha) in lipopolysaccharide (LPS)-induced RAW 264.7 cells, along with suppressing the mRNA expression of these inflammatory markers.

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