New Isocoumarin and Pyrone Derivatives from the Chinese Mangrove Plant Rhizophora mangle-Associated Fungus Phomopsis sp. DHS-11

文献类型： 外文期刊

第一作者： Guo, Zhikai

作者： Guo, Zhikai;Chen, Biting;Yuan, Jingzhe;Zhang, Shiqing;Xiong, Zijun;Guo, Zhikai;Chen, Biting;Yuan, Jingzhe;Zhang, Shiqing;Xiong, Zijun;Chen, Biting;Chen, Dandan;Deng, Xiaoling;Xu, Jing

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关键词： mangrove; endophytic fungus; Phomopsis sp.; polyketides; cytotoxic activity

期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：4.9 ）

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年卷期： 2023 年 28 卷 9 期

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收录情况： SCI

摘要： Mangrove-associated fungi are important sources for the discovery of new bioactive natural products. Three new isocoumarins (1-3) and one new pyrone derivative (4) were isolated from the ethyl acetate extract of the fermentation broth of the mangrove endophytic fungus Phomopsis sp. DHS-11. Nuclear magnetic resonance (NMR) spectroscopy (one-dimensional and two-dimensional) and mass spectrometry were used to determine the structures of these new compounds. The absolute configurations for the new isocoumarins 1-3 were determined by comparing their experimental and calculated electronic circular dichroism (ECD) spectra, while the configuration for the new pyrone-derivative 4 was tentatively solved by comparison of its C-13 NMR data with reported data. In the biological activity test, compounds 1 and 3 showed cytotoxic activity against HeLa cells with IC50 values of 11.49 +/- 1.64 mu M and 8.70 +/- 0.94 mu M, respectively. The initial structure and activity relationship (SAR) analysis revealed that the length of the side chain at C-3 for isocoumarin-type compounds 1-3 could affect the cytotoxicity against HeLa cells. Compound 4 exhibited cytotoxic activities against human hepatoma cells HepG2 with an IC50 value of 34.10 +/- 2.92 mu M. All compounds have no immunosuppressive activity.

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