Regulatory mechanisms of Beta-carotene and BCMO1 in adipose tissues: A gene enrichment-based bioinformatics analysis

文献类型： 外文期刊

第一作者： Wang, Yutao

作者： Wang, Yutao;Zhao, Yuhua;Liu, Pingxiang;Cai, Da;Zhang, Xiao;Gao, Lei;Wang, Yutao;Zhao, Yuhua;Liu, Pingxiang;Cai, Da;Zhang, Xiao;Gao, Lei;Wang, Jinshen

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关键词： beta-carotene; BCMO1; bioinformatic analysis; fat metabolism

期刊名称：HUMAN & EXPERIMENTAL TOXICOLOGY （ 影响因子：2.903； 五年影响因子：2.712 ）

ISSN： 0960-3271

年卷期： 2022 年 41 卷

页码：

收录情况： SCI

摘要： Beta-carotene (beta-carotene, BC) is one of the carotenoids most commonly consumed by humans. BCMO1 is expressed in various human tissues and is considered to be a key enzyme that converts BC into vitamin A. Studies indicated that BC-derived carotenoid signaling molecules affected the physiological functions of fat cells. In order to investigate the role and possible molecular mechanism of BC in mouse adipocytes, we conducted 4-group and 2-group difference analysis based on the data of GSE27271 chip in the Gene Expression Omnibus database. Genes differentially expressed in the inguinal white adipose tissue of mice were screened out and combined with the STRING database to construct protein-protein interaction (PPI) networks. Among them, Alb (albumin), Mug1 (murinoglobulin-1) and Uox (urate oxidase) genes were at relatively key positions and may affect the action of BC. Besides, Ppara (peroxisome proliferator-activated receptor alpha), Acly (ATP-citrate lyase) and Fabp5 (fatty acid-binding protein 5) genes constituted functional partners with many genes in the PPI network, and these genes may be Bcmo1 targeting molecules. Gene Ontology (GO) function and signaling pathways enrichment analysis were performed on the genes with protein interaction relationship in the PPI network. Fatty acid binding, cholesterol metabolic process, and regulation of fatty acid metabolic process were significantly enriched, and PPAR signaling pathway showed the most significant, indicating that BC and Bcmo1 might synergistically affect body metabolic functions such as fat metabolism. In general, BC and Bcmo1 may play a role in fat metabolism in mice, thereby affecting other functions or diseases.

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