The Roles of N6-Methyladenosine Modification in Plant-RNA Virus Interactions

文献类型： 外文期刊

第一作者： He, Min

作者： He, Min;Xie, Xin;He, Min;Li, Zhiqiang

作者机构：

关键词： m(6)A; RNA virus; infection; plant

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.6； 五年影响因子：6.2 ）

ISSN： 1661-6596

年卷期： 2023 年 24 卷 21 期

页码：

收录情况： SCI

摘要： N-6-methyladenosine (m(6)A) is a dynamic post-transcriptional RNA modification. Recently, its role in viruses has led to the study of viral epitranscriptomics. m(6)A has been observed in viral genomes and alters the transcriptomes of both the host cell and virus during infection. The effects of m(6)A modifications on host plant mRNA can either increase the likelihood of viral infection or enhance the resistance of the host to the virus. However, to date, the regulatory mechanisms of m(6)A in viral infection and host immune responses have not been fully elucidated. With the development of sequencing-based biotechnologies, the study of m(6)A in plant viruses has received increasing attention. In this mini review, we summarize the positive and negative consequences of m(6)A modification in different RNA viral infections. Given its increasingly important roles in multiple viruses, m(6)A represents a new potential target for antiviral defense.

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