Genetic diversity of Toll-like receptor 9 in swamp eels (Monopterus albus)

文献类型： 外文期刊

第一作者： Huo, Caifei

作者： Huo, Caifei;Rao, Han;Zeng, Bo;Li, Debing;Li, Yan;Tian, Haifeng;Li, Zhong;Zeng, Bo;Li, Yan;Zeng, Bo;Li, Yan;Zeng, Bo;Li, Yan

作者机构：

关键词： genetic diversity; Monopterus albus; Monopterus javanensis; Toll-like receptor 9 (TLR9)

期刊名称：JOURNAL OF FISH BIOLOGY （ 影响因子：2.0； 五年影响因子：1.9 ）

ISSN： 0022-1112

年卷期： 2023 年

页码：

收录情况： SCI

摘要： The swamp eel, Monopterus albus, is an important aquaculture species in Asia (mainly China) whose production has seriously suffered from infectious diseases. In spite of the critical requirement for aquaculture practices, to date there is scant information on its immune defence. Here, the genetic characteristics of Toll-like receptor 9 (TLR9), which plays crucial roles in the initiation of host defence against microbial invasion, were analysed. It exhibits a striking lack of genetic variation resulting from a recent demographic bottleneck. A comparison with the homologue of M. javanensis revealed that replacement but not silent differences have nonrandomly accumulated in the coding sequences at the early stage following their split from a common ancestor. Furthermore, the replacements relevant to the type II functional divergence have mainly occurred in structural motifs mediating ligand recognition and receptor homodimerization. These results provide hints to understand the diversity-based strategy of TLR9 in the arms race against pathogens. Furthermore, the findings reported here give credence to the importance of basic immunology knowledge, especially for the key elements, in genetic engineering and breeding for disease resistance in the eel and other fishes.

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