Betaine improves appetite regulation and glucose-lipid metabolism in mandarin fish (Siniperca chuatsi) fed a high-carbohydrate-diet by regulating the AMPK/mTOR signaling

文献类型： 外文期刊

第一作者： Li, Hongyan

作者： Li, Hongyan;Zeng, Yanzhi;Wang, Guangjun;Zhang, Kai;Gong, Wangbao;Li, Zhifei;Tian, Jingjing;Xia, Yun;Xie, Wenping;Xie, Jun;Yu, Ermeng;Li, Hongyan;Xie, Shouqi;Li, Hongyan;Zeng, Yanzhi

作者机构：

关键词： Mandarin fish; Betaine; AMPK/mTOR; Appetite regulation; Glucose-lipid metabolism

期刊名称：HELIYON （ 影响因子：4.0； 五年影响因子：4.1 ）

ISSN：

年卷期： 2024 年 10 卷 7 期

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收录情况： SCI

摘要： Diets with high carbohydrate (HC) was reported to have influence on appetite and intermediary metabolism in fish. To illustrate whether betaine could improve appetite and glucose-lipid metabolism in aquatic animals, mandarin fish (Siniperca chuatsi) were fed with the HC diets with or without betaine for 8 weeks. The results suggested that betaine enhanced feed intake by regulating the hypothalamic appetite genes. The HC diet-induced downregulation of AMPK and appetite genes was also positively correlated with the decreased autophagy genes, suggesting a possible mechanism that AMPK/mTOR signaling might regulate appetite through autophagy. The HC diet remarkably elevated transcriptional levels of genes related to lipogenesis, while betaine alleviated the HC-induced hepatic lipid deposition. Additionally, betaine supplementation tended to store the energy storage as hepatic glycogen. Our findings proposed the possible mechanism for appetite regulation through autophagy via AMPK/mTOR, and demonstrated the feasibility of betaine as an aquafeed additive to regulate appetite and intermediary metabolism in fish.

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