Bisphenol A Exposure Interferes with Reproductive Hormones and Decreases Sperm Counts: A Systematic Review and Meta-Analysis of Epidemiological Studies

文献类型： 外文期刊

第一作者： Lue, Lei

作者： Lue, Lei;Liu, Yuan;Yang, Yuhong;He, Jinxing;Luo, Lulu;Xing, Hanzhu;Chen, Shanbin

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关键词： endocrine disruptors; male fertility; reproductive hormones; risk of below-reference sperm quality; sperm counts; bisphenol A

期刊名称：TOXICS （ 影响因子：4.6； 五年影响因子：4.8 ）

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年卷期： 2024 年 12 卷 4 期

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收录情况： SCI

摘要： Bisphenol A (BPA), an acknowledged endocrine disrupter, is easily exposed to humans via food packaging and container. However, a consensus has not been reached on the extent to which BPA exposure affects the reproductive system. We therefore conducted this systematic review and meta-analysis to elucidate the relationship between BPA exposure and male reproduction-related indicators. Up to October 2023, a comprehensive search was carried out in the PubMed, Embase, Cochrane and Web of Science, and 18 studies were ultimately included. beta coefficients from multivariate linear regression analyses were pooled using a random effects model. The results showed that the urinary BPA concentration was negatively correlated with the sperm concentration (beta coefficient = -0.03; 95% CI: -0.06 to -0.01; I-2 = 0.0%, p = 0.003) and total sperm count (beta coefficient = -0.05; 95% CI: -0.08 to -0.02; I-2 = 0.0%, p < 0.001). In addition, BPA concentrations were associated with increased sex hormone-binding globulin (SHBG) levels, increased estradiol (E-2) levels, and reduced biologically active androgen levels. However, the relationship between an increased risk of below-reference sperm quality and BPA exposure was not robust. This systematic review revealed that BPA exposure disrupts reproductive hormones, reduces sperm counts and may ultimately adversely affect male reproduction.

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