Trace analysis of progesterone and 21 progestins in milk by ultra-performance liquid chromatography coupled with high-field quadrupole-orbitrap high-resolution mass spectrometry

文献类型： 外文期刊

第一作者： Suo Decheng

作者： Suo Decheng;fan xia;Xiao Zhiming;Wei Shulin;Wang Shi;Wang Peilong

作者机构：

关键词： Progesterone; Progestins; Milk; High-performance liquid chromatography quadrupole-Orbitrap high-resolution mass spectrometry

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

ISSN： 0308-8146

年卷期： 2021 年 361 卷

页码：

收录情况： SCI

摘要： A method for rapid screening and quantification of progesterone and progestins in milks by ultrahighperformance liquid chromatography coupled with quadrupole-high field Orbitrap high-resolution mass spectrometry (UHPLC QE HF HRMS) was established. Milks samples were extracted by acetonitrile + hexane (80 + 20), purified by prime HLB SPE and analyzed by UHPLC QE HF HRMS. The detection limit of progesterone and 21 progestins in milk is between 0.05 mu g/kg -0.3 mu g /kg, the correlation coefficient of progesterone and progestins in the corresponding concentration range is more than 0.99, recoveries for milk samples are between 80.7% and 108.3% with the relative deviation is less than 15%.The method fulfils the requirements of veterinary drug residue detection validation of EU and China, and successfully applied to detecting the mu g/kg level of progesterone and monitoring residual of progestins in real milk.

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