文献类型： 外文期刊

第一作者： Terlouw, Barbara R.

作者： Terlouw, Barbara R.;Navarro-Munoz, Jorge C.;Meijer, David;Reitz, Zachary L.;Alanjary, Mohammad;Augustijn, Hannah E.;Biermann, Friederike;van der Hooft, Justin J. J.;Louwen, Joris J. R.;Louwen, Nico L. L.;Pronk, Lotte J. U.;Singh, Kumar Saurabh;Vromans, Sophie P. J. M.;Xie, Huali;Zdouc, Mitja;Medema, Marnix H.;Blin, Kai;Booth, Thomas J.;Cruz-Morales, Pablo;Weber, Tilmann;Navarro-Munoz, Jorge C.;Kalyvas, Nikolaos;Collemare, Jerome;Avalon, Nicole E.;Chevrette, Marc G.;Egbert, Susan;Lee, Sanghoon;Recchia, Michael J. J.;van Santen, Jeffrey A.;Zaroubi, Liana;Linington, Roger G.;van Santen, Jeffrey A.;Selem-Mojica, Nelly;Torring, Thomas;Aleti, Gajender;Aguilar, Cesar;Al-Salihi, Suhad A. A.;Augustijn, Hannah E.;Avitia-Dominguez, Luis A.;Barona-Gomez, Francisco;Bravo, Victor J. Carrion;Du, Chao;Rosas-Becerra, L. Rodrigo;Medema, Marnix H.;Avelar-Rivas, J. Abraham;Avitia-Dominguez, Luis A.;Barona-Gomez, Francisco;Rosas-Becerra, L. Rodrigo;Bernaldo-Aguero, Jordan;Bielinski, Vincent A.;Biermann, Friederike;Helfrich, Eric J. N.;Biermann, Friederike;Helfrich, Eric J. N.;Booth, Thomas J.;Bravo, Victor J. Carrion;Bravo, Victor J. Carrion;Castelo-Branco, Raquel;Rego, Adriana;Castelo-Branco, Raquel;Chagas, Fernanda O.;Duncan, Katherine R.;Scobie, Darren J.;Gavriilidou, Athina;Pourmohsenin, Bita;Gavriilidou, Athina;Pourmohsenin, Bita;Gayrard, Damien;Gutierrez-Garcia, Karina;Haslinger, Kristina;Sokolova, Nika;van der Hooft, Justin J. J.;Jati, Afif P.;Kalkreuter, Edward;Kautsar, Satria;Kang, Kyo B.;Kim, Wonyong;Kunjapur, Aditya M.;Li, Yong-Xin;Lin, Geng-Min;Loureiro, Catarina;Schorn, Michelle A.;Zhong, Zheng;Lund, George;Parra, Jonathan;Parra, Jonathan;Parra, Jonathan;Philmus, Benjamin;Rego, Adriana;Rex, Devasahayam Arokia Balaya;Robinson, Serina;Roxborough, Eve T.;Tang, Xiaoyu;Udwary, Daniel;Vigneshwari, Aruna;Vind, Kristiina;Vind, Kristiina;Waschulin, Valentin;Williams, Sam E.;Winter, Jaclyn M.;Witte, Thomas E.;Xie, Huali;Yang, Dong;Yu, Jingwei

作者机构：

期刊名称：NUCLEIC ACIDS RESEARCH （ 影响因子：14.9； 五年影响因子：16.4 ）

ISSN： 0305-1048

年卷期： 2022 年

页码：

收录情况： SCI

摘要： With an ever-increasing amount of (meta)genomic data being deposited in sequence databases, (meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protection agents and biomaterials. The genes that encode these pathways are often organised into biosynthetic gene clusters (BGCs). In 2015, we defined the Minimum Information about a Biosynthetic Gene cluster (MIBiG): a standardised data format that describes the minimally required information to uniquely characterise a BGC. We simultaneously constructed an accompanying online database of BGCs, which has since been widely used by the community as a reference dataset for BGCs and was expanded to 2021 entries in 2019 (MIBiG 2.0). Here, we describe MIBiG 3.0, a database update comprising large-scale validation and re-annotation of existing entries and 661 new entries. Particular attention was paid to the annotation of compound structures and biological activities, as well as protein domain selectivities. Together, these new features keep the database upto-date, and will provide new opportunities for the scientific community to use its freely available data, e.g. for the training of new machine learning models to predict sequence-structure-function relationships for diverse natural products. MIBiG 3.0 is accessible online at https://mibig.secondarymetabolites.org/. [GRAPHICS] .

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