Phosphoribosylpyrophosphate synthetase as a metabolic valve advances Methylobacterium/Methylorubrum phyllosphere colonization and plant growth

文献类型： 外文期刊

第一作者： Zhang, Cong

作者： Zhang, Cong;Zhou, Di-Fei;Wang, Meng-Ying;Song, Ya-Zhen;Zhang, Ming-Ming;Sun, Jing;Mo, Xu-Hua;Ma, Zeng-Xin;Yuan, Xiao-Jie;Shao, Yi;Wang, Hao-Ran;Dong, Si-Han;Yang, Song;Zhang, Cong;Zhou, Di-Fei;Wang, Meng-Ying;Song, Ya-Zhen;Zhang, Ming-Ming;Sun, Jing;Mo, Xu-Hua;Ma, Zeng-Xin;Yuan, Xiao-Jie;Shao, Yi;Wang, Hao-Ran;Dong, Si-Han;Yang, Song;Zhang, Cong;Zhou, Di-Fei;Wang, Meng-Ying;Song, Ya-Zhen;Zhang, Ming-Ming;Sun, Jing;Mo, Xu-Hua;Ma, Zeng-Xin;Yuan, Xiao-Jie;Shao, Yi;Wang, Hao-Ran;Dong, Si-Han;Yang, Song;Zhang, Chong;Xing, Xin-Hui;Zhang, Chong;Xing, Xin-Hui;Yao, Lu;Bao, Kai;Lu, Shu-Huan;Sadilek, Martin;Kalyuzhnaya, Marina G.;Xing, Xin-Hui;Xing, Xin-Hui;Yang, Song;Yang, Song

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.7； 五年影响因子：16.1 ）

ISSN：

年卷期： 2024 年 15 卷 1 期

页码：

收录情况： SCI

摘要： The proficiency of phyllosphere microbiomes in efficiently utilizing plant-provided nutrients is pivotal for their successful colonization of plants. The methylotrophic capabilities of Methylobacterium/Methylorubrum play a crucial role in this process. However, the precise mechanisms facilitating efficient colonization remain elusive. In the present study, we investigate the significance of methanol assimilation in shaping the success of mutualistic relationships between methylotrophs and plants. A set of strains originating from Methylorubrum extorquens AM1 are subjected to evolutionary pressures to thrive under low methanol conditions. A mutation in the phosphoribosylpyrophosphate synthetase gene is identified, which converts it into a metabolic valve. This valve redirects limited C1-carbon resources towards the synthesis of biomass by up-regulating a non-essential phosphoketolase pathway. These newly acquired bacterial traits demonstrate superior colonization capabilities, even at low abundance, leading to increased growth of inoculated plants. This function is prevalent in Methylobacterium/Methylorubrum strains. In summary, our findings offer insights that could guide the selection of Methylobacterium/Methylorubrum strains for advantageous agricultural applications.

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