Genomic and stress resistance characterization of Lactiplantibacillus plantarum GX17, a potential probiotic for animal feed applications

文献类型： 外文期刊

第一作者： Yin, Yangyan

作者： Yin, Yangyan;Li, Chunling;Bai, Huili;Ma, Chunxia;Lan, Meiyi;Teng, Ling;Yin, Yangyan;Li, Chunling;Li, Changting;Chen, Zhongwei;Bai, Huili;Ma, Chunxia;Lan, Meiyi;Li, Jun;Teng, Ling;Wang, Leping;Qin, Zhongsheng;Peng, Hao;Yin, Yangyan;Li, Chunling;Li, Changting;Chen, Zhongwei;Bai, Huili;Ma, Chunxia;Lan, Meiyi;Li, Jun;Teng, Ling;Wang, Leping;Qin, Zhongsheng;Peng, Hao;Pei, Zhe;Gong, Yu;Liu, Jing;Zhang, Ezhen

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关键词： Lactiplantibacillus plantarum GX17; genome-wide; gene prediction; stress resistance genes; stress resistance

期刊名称：MICROBIOLOGY SPECTRUM （ 影响因子：3.8； 五年影响因子：4.1 ）

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年卷期： 2025 年

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收录情况： SCI

摘要： Lactobacilli, recognized as beneficial bacteria within the human body, are celebrated for their multifaceted probiotic functions, including the regulation of intestinal flora, enhancement of body immunity, and promotion of nutrient absorption. This study comprehensively analyzed the genotypic and phenotypic characteristics of Lactiplantibacillus plantarum (L. plantarum) strains isolated from the intestines of healthy chicks and assessed their potential as probiotics. The assembled genome consists of 29,521,986 bp, and a total of 1,771 coding sequences (CDSs) were predicted. Based on the entire genome sequence analysis, 50 stress resistance genes and seven virulence factors were identified. The results of the phenotypic experiments showed that the strain had good resistance to high temperature, low temperature, acid, alkali, salt, artificial gastrointestinal fluid, and strong antioxidant capacity. Additionally, transcriptomic analysis confirmed that under stress conditions, the expression levels of key genes were significantly upregulated. Therefore, the phenotypic characteristics of L. plantarum GX17 align well with its genotypic features, demonstrating promising probiotic properties. This strain holds great potential as a probiotic candidate, and further investigation into its beneficial effects on human health is warranted.IMPORTANCEIn humans, Lactiplantibacillus plantarum may synergize with host microbiota to ameliorate dysbiosis-related pathologies, enhance immunomodulation, and facilitate micronutrient bioavailability. For livestock, its application could improve feed conversion ratios, suppress enteric pathogens through competitive exclusion, and mitigate antibiotic overuse, "a critical strategy in One Health frameworks." Further investigations into strain-specific mechanisms (e.g., postbiotic metabolites, quorum sensing regulation) are warranted to translate these genomic-phenotypic advantages into sustainable health solutions across species.

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